Detailed information of TA system TA041775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1619448..1620116
• Replicon: chromosome
• Accession: NZ_AP025938
• Organism: Streptococcus pneumoniae strain PZ900701057

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: QMM10_RS08085
• Protein ID: WP_025169096.1
• Coordinates: 1619937..1620116 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: QMM10_RS08080
• Protein ID: WP_000961810.1
• Coordinates: 1619448..1619900 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMM10_RS08055 (PC1044_15950)	1615338..1616081	-	744	WP_001188207.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
QMM10_RS08060 (PC1044_15960)	1616083..1617033	-	951	WP_281737539.1	50S ribosomal protein L11 methyltransferase	-
QMM10_RS08065 (PC1044_15970)	1617171..1617599	-	429	WP_000401988.1	NUDIX hydrolase	-
QMM10_RS08070 (PC1044_15980)	1617601..1618668	-	1068	WP_000719721.1	site-2 protease family protein	-
QMM10_RS08075 (PC1044_15990)	1618687..1619157	-	471	WP_050207051.1	DUF3013 family protein	-
QMM10_RS08080 (PC1044_16000)	1619448..1619900	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
QMM10_RS08085 (PC1044_16010)	1619937..1620116	-	180	WP_025169096.1	type II toxin-antitoxin system HicA family toxin	Toxin
QMM10_RS08090 (PC1044_16020)	1620253..1620432	-	180	WP_001809903.1	hypothetical protein	-
QMM10_RS08095	1620597..1620835	-	239	Protein_1602	hypothetical protein	-
QMM10_RS08100 (PC1044_16030)	1621105..1622376	+	1272	WP_001113208.1	replication-associated recombination protein A	-
QMM10_RS08110 (PC1044_16040)	1622922..1624241	-	1320	WP_000502548.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6578.75 Da
• Isoelectric Point: 10.8214

>T41775 WP_025169096.1 NZ_AP025938:c1620116-1619937 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 180 bp

>T41775 NZ_AP025938:c1620116-1619937 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT41775 WP_000961810.1 NZ_AP025938:c1619900-1619448 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT41775 NZ_AP025938:c1619900-1619448 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Antitoxin

• AlphaFold DB: G0IC64