Detailed information of TA system TA041772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1548990..1549658
• Replicon: chromosome
• Accession: NZ_AP025937
• Organism: Streptococcus pneumoniae strain PZ900700792

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: QML92_RS07715
• Protein ID: WP_001132283.1
• Coordinates: 1549479..1549658 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: QML92_RS07710
• Protein ID: WP_000961810.1
• Coordinates: 1548990..1549442 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QML92_RS07680 (PC0780_15320)	1544844..1545587	-	744	WP_001188213.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
QML92_RS07685 (PC0780_15330)	1545589..1546542	-	954	WP_000970781.1	50S ribosomal protein L11 methyltransferase	-
QML92_RS07690 (PC0780_15340)	1546677..1547150	-	474	WP_000631889.1	GNAT family N-acetyltransferase	-
QML92_RS07695 (PC0780_15350)	1547147..1547581	-	435	WP_000421871.1	NUDIX hydrolase	-
QML92_RS07700 (PC0780_15360)	1547631..1548173	-	543	WP_000891117.1	hypothetical protein	-
QML92_RS07705 (PC0780_15370)	1548229..1548699	-	471	WP_000257097.1	DUF3013 family protein	-
QML92_RS07710 (PC0780_15380)	1548990..1549442	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
QML92_RS07715 (PC0780_15390)	1549479..1549658	-	180	WP_001132283.1	type II toxin-antitoxin system HicA family toxin	Toxin
QML92_RS07720 (PC0780_15400)	1549795..1549974	-	180	WP_001809903.1	hypothetical protein	-
QML92_RS07725 (PC0780_15410)	1550139..1550378	-	240	WP_000818079.1	hypothetical protein	-
QML92_RS07730 (PC0780_15420)	1550648..1551919	+	1272	WP_001113216.1	replication-associated recombination protein A	-
QML92_RS07740 (PC0780_15430)	1552339..1553466	-	1128	WP_000323402.1	tyrosine-type recombinase/integrase	-
QML92_RS07745 (PC0780_15440)	1553468..1553650	-	183	WP_000785802.1	DUF3173 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6596.78 Da
• Isoelectric Point: 10.8214

>T41772 WP_001132283.1 NZ_AP025937:c1549658-1549479 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 180 bp

>T41772 NZ_AP025937:c1549658-1549479 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT41772 WP_000961810.1 NZ_AP025937:c1549442-1548990 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT41772 NZ_AP025937:c1549442-1548990 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Antitoxin

• PDB: 5YRZ
• AlphaFold DB: G0IC64