Detailed information of TA system TA041768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1550372..1551040
• Replicon: chromosome
• Accession: NZ_AP025936
• Organism: Streptococcus pneumoniae strain PZ900700617

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: QML87_RS07735
• Protein ID: WP_001132283.1
• Coordinates: 1550861..1551040 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: QML87_RS07730
• Protein ID: WP_000961810.1
• Coordinates: 1550372..1550824 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QML87_RS07700 (PC0607_15330)	1546226..1546969	-	744	WP_001188213.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
QML87_RS07705 (PC0607_15340)	1546971..1547924	-	954	WP_000970781.1	50S ribosomal protein L11 methyltransferase	-
QML87_RS07710 (PC0607_15350)	1548059..1548532	-	474	WP_000631889.1	GNAT family N-acetyltransferase	-
QML87_RS07715 (PC0607_15360)	1548529..1548963	-	435	WP_000421871.1	NUDIX hydrolase	-
QML87_RS07720 (PC0607_15370)	1549013..1549555	-	543	WP_000891117.1	hypothetical protein	-
QML87_RS07725 (PC0607_15380)	1549611..1550081	-	471	WP_000257097.1	DUF3013 family protein	-
QML87_RS07730 (PC0607_15390)	1550372..1550824	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
QML87_RS07735 (PC0607_15400)	1550861..1551040	-	180	WP_001132283.1	type II toxin-antitoxin system HicA family toxin	Toxin
QML87_RS07740 (PC0607_15410)	1551177..1551356	-	180	WP_001809903.1	hypothetical protein	-
QML87_RS07745 (PC0607_15420)	1551521..1551760	-	240	WP_000818079.1	hypothetical protein	-
QML87_RS07750 (PC0607_15430)	1552030..1553301	+	1272	WP_001113216.1	replication-associated recombination protein A	-
QML87_RS07760 (PC0607_15440)	1553721..1554848	-	1128	WP_000323402.1	tyrosine-type recombinase/integrase	-
QML87_RS07765 (PC0607_15450)	1554850..1555032	-	183	WP_000785802.1	DUF3173 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6596.78 Da
• Isoelectric Point: 10.8214

>T41768 WP_001132283.1 NZ_AP025936:c1551040-1550861 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 180 bp

>T41768 NZ_AP025936:c1551040-1550861 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAG
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT41768 WP_000961810.1 NZ_AP025936:c1550824-1550372 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT41768 NZ_AP025936:c1550824-1550372 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Antitoxin

• PDB: 5YRZ
• AlphaFold DB: G0IC64