Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4835860..4836464 Replicon chromosome
Accession NZ_AP025927
Organism Enterobacter hormaechei strain FUJ80381

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag NGK75_RS23440 Protein ID WP_071788668.1
Coordinates 4836279..4836464 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag NGK75_RS23435 Protein ID WP_023295606.1
Coordinates 4835860..4836264 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK75_RS23420 (FJMB80381_46030) 4831400..4832218 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
NGK75_RS23425 (FJMB80381_46040) 4832444..4833844 + 1401 WP_017693791.1 MFS transporter -
NGK75_RS23430 (FJMB80381_46050) 4833855..4835804 + 1950 WP_032649830.1 glycoside hydrolase family 127 protein -
NGK75_RS23435 (FJMB80381_46060) 4835860..4836264 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NGK75_RS23440 4836279..4836464 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
NGK75_RS23445 (FJMB80381_46070) 4836714..4838252 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
NGK75_RS23450 (FJMB80381_46080) 4838419..4839303 + 885 WP_003860164.1 ROK family protein -
NGK75_RS23455 (FJMB80381_46090) 4839307..4841145 - 1839 WP_017693788.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T41744 WP_071788668.1 NZ_AP025927:c4836464-4836279 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T41744 NZ_AP025927:c4836464-4836279 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT41744 WP_023295606.1 NZ_AP025927:c4836264-4835860 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT41744 NZ_AP025927:c4836264-4835860 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTCCCGGGTAGTGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References