Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2519793..2520532 Replicon chromosome
Accession NZ_AP025927
Organism Enterobacter hormaechei strain FUJ80381

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NGK75_RS12190 Protein ID WP_003857133.1
Coordinates 2520047..2520532 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK75_RS12185 Protein ID WP_003857131.1
Coordinates 2519793..2520059 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK75_RS12165 (FJMB80381_23870) 2515275..2516261 + 987 WP_017382341.1 DUF979 domain-containing protein -
NGK75_RS12170 (FJMB80381_23880) 2516271..2517266 + 996 WP_017382342.1 DUF2891 domain-containing protein -
NGK75_RS12175 (FJMB80381_23890) 2517288..2518670 - 1383 WP_032648336.1 MFS transporter -
NGK75_RS12180 (FJMB80381_23900) 2518800..2519729 + 930 WP_032648334.1 LysR family transcriptional regulator -
NGK75_RS12185 (FJMB80381_23910) 2519793..2520059 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK75_RS12190 (FJMB80381_23920) 2520047..2520532 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NGK75_RS12195 (FJMB80381_23930) 2520583..2521152 - 570 WP_032648331.1 hypothetical protein -
NGK75_RS12200 (FJMB80381_23940) 2521168..2522133 - 966 WP_032648329.1 hypothetical protein -
NGK75_RS12205 (FJMB80381_23950) 2522391..2523005 - 615 WP_065420578.1 NUDIX hydrolase -
NGK75_RS12210 (FJMB80381_23970) 2523005..2524297 - 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NGK75_RS12215 (FJMB80381_23980) 2524402..2525160 - 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T41741 WP_003857133.1 NZ_AP025927:2520047-2520532 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41741 NZ_AP025927:2520047-2520532 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41741 WP_003857131.1 NZ_AP025927:2519793-2520059 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41741 NZ_AP025927:2519793-2520059 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References