41705

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4269564..4270243 Replicon chromosome
Accession NZ_AP025919
Organism Enterobacter hormaechei strain FUJ80378

Toxin (Protein)


Gene name ykfI Uniprot ID A0A411GL63
Locus tag NGK71_RS20550 Protein ID WP_016243829.1
Coordinates 4269564..4269905 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8B2XJW9
Locus tag NGK71_RS20555 Protein ID WP_016243830.1
Coordinates 4269926..4270243 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK71_RS20530 (FJMB80378_40390) 4264863..4266666 + 1804 Protein_4017 DNA primase -
NGK71_RS20535 (FJMB80378_40400) 4266761..4268605 + 1845 WP_015571912.1 RNA polymerase sigma factor RpoD -
NGK71_RS20540 (FJMB80378_40410) 4268696..4269202 - 507 WP_032649590.1 G/U mismatch-specific DNA glycosylase -
NGK71_RS20550 (FJMB80378_40420) 4269564..4269905 - 342 WP_016243829.1 TA system toxin CbtA family protein Toxin
NGK71_RS20555 (FJMB80378_40430) 4269926..4270243 - 318 WP_016243830.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NGK71_RS20560 (FJMB80378_40440) 4270264..4270485 - 222 WP_007777714.1 DUF987 domain-containing protein -
NGK71_RS20565 (FJMB80378_40450) 4270494..4270970 - 477 WP_016243831.1 RadC family protein -
NGK71_RS20570 (FJMB80378_40460) 4270986..4271444 - 459 WP_016243832.1 antirestriction protein -
NGK71_RS20575 (FJMB80378_40470) 4271546..4271785 - 240 WP_016243833.1 DUF905 domain-containing protein -
NGK71_RS20580 (FJMB80378_40480) 4271862..4272329 - 468 WP_016239439.1 protein YkfB -
NGK71_RS20585 (FJMB80378_40490) 4272353..4272796 - 444 WP_016243834.1 hypothetical protein -
NGK71_RS20590 (FJMB80378_40500) 4272796..4273032 - 237 WP_001115854.1 protein YpjK -
NGK71_RS20595 (FJMB80378_40510) 4273069..4273770 - 702 WP_251266445.1 WYL domain-containing protein -
NGK71_RS20600 (FJMB80378_40520) 4273987..4274808 - 822 WP_008324532.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13020.04 Da        Isoelectric Point: 9.9961

>T41705 WP_016243829.1 NZ_AP025919:c4269905-4269564 [Enterobacter hormaechei]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGISLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRKNSVR

Download         Length: 342 bp

>T41705 NZ_AP025919:c4269905-4269564 [Enterobacter hormaechei]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGGATCTCGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAAAAATTCGGTACGGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12041.72 Da        Isoelectric Point: 7.7518

>AT41705 WP_016243830.1 NZ_AP025919:c4270243-4269926 [Enterobacter hormaechei]
MTHITWGLQRNITPRLGARLVQEGNRMHYLADRASITGKFSDTECRKLDETFPHFIRQMESMLTTGEMNPRNAHCVTLFH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT41705 NZ_AP025919:c4270243-4269926 [Enterobacter hormaechei]
ATGACTCACATCACATGGGGCCTGCAGCGGAATATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGGAACCGGAT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCAATGCCCACTGTGTCACCCTGTTCCAC
AACGGTTTCACCTGTGAAGCCGACACCCTTGGCAGTTGCGGTTACGTGTACATCGCCATTTATCCCACCCAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411GL63

Antitoxin

Source ID Structure
AlphaFold DB A0A8B2XJW9

References