41694

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2441871..2442610 Replicon chromosome
Accession NZ_AP025919
Organism Enterobacter hormaechei strain FUJ80378

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NGK71_RS11665 Protein ID WP_003857133.1
Coordinates 2441871..2442356 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK71_RS11670 Protein ID WP_003857131.1
Coordinates 2442344..2442610 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK71_RS11640 (FJMB80378_22820) 2437243..2438001 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
NGK71_RS11645 (FJMB80378_22830) 2438106..2439398 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NGK71_RS11650 (FJMB80378_22850) 2439398..2440012 + 615 WP_065420578.1 NUDIX hydrolase -
NGK71_RS11655 (FJMB80378_22860) 2440270..2441235 + 966 WP_032648329.1 hypothetical protein -
NGK71_RS11660 (FJMB80378_22870) 2441251..2441820 + 570 WP_032648331.1 hypothetical protein -
NGK71_RS11665 (FJMB80378_22880) 2441871..2442356 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NGK71_RS11670 (FJMB80378_22890) 2442344..2442610 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK71_RS11675 (FJMB80378_22900) 2442674..2443603 - 930 WP_032648334.1 LysR family transcriptional regulator -
NGK71_RS11680 (FJMB80378_22910) 2443733..2445115 + 1383 WP_032648336.1 MFS transporter -
NGK71_RS11685 (FJMB80378_22920) 2445137..2446132 - 996 WP_017382342.1 DUF2891 domain-containing protein -
NGK71_RS11690 (FJMB80378_22930) 2446142..2447128 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T41694 WP_003857133.1 NZ_AP025919:c2442356-2441871 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41694 NZ_AP025919:c2442356-2441871 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41694 WP_003857131.1 NZ_AP025919:c2442610-2442344 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41694 NZ_AP025919:c2442610-2442344 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References