Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2519796..2520535 Replicon chromosome
Accession NZ_AP025915
Organism Enterobacter hormaechei strain FUJ80377

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NGK73_RS12195 Protein ID WP_003857133.1
Coordinates 2520050..2520535 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK73_RS12190 Protein ID WP_003857131.1
Coordinates 2519796..2520062 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK73_RS12170 (FJMB80377_23830) 2515278..2516264 + 987 WP_017382341.1 DUF979 domain-containing protein -
NGK73_RS12175 (FJMB80377_23840) 2516274..2517269 + 996 WP_017382342.1 DUF2891 domain-containing protein -
NGK73_RS12180 (FJMB80377_23850) 2517291..2518673 - 1383 WP_032648336.1 MFS transporter -
NGK73_RS12185 (FJMB80377_23860) 2518803..2519732 + 930 WP_032648334.1 LysR family transcriptional regulator -
NGK73_RS12190 (FJMB80377_23870) 2519796..2520062 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK73_RS12195 (FJMB80377_23880) 2520050..2520535 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NGK73_RS12200 (FJMB80377_23890) 2520586..2521155 - 570 WP_032648331.1 hypothetical protein -
NGK73_RS12205 (FJMB80377_23900) 2521171..2522136 - 966 WP_032648329.1 hypothetical protein -
NGK73_RS12210 (FJMB80377_23910) 2522394..2523008 - 615 WP_065420578.1 NUDIX hydrolase -
NGK73_RS12215 (FJMB80377_23930) 2523008..2524300 - 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NGK73_RS12220 (FJMB80377_23940) 2524405..2525163 - 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T41683 WP_003857133.1 NZ_AP025915:2520050-2520535 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41683 NZ_AP025915:2520050-2520535 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41683 WP_003857131.1 NZ_AP025915:2519796-2520062 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41683 NZ_AP025915:2519796-2520062 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References