Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | KacT-ataR/DUF1778(antitoxin) |
Location | 1866524..1867321 | Replicon | chromosome |
Accession | NZ_AP025907 | ||
Organism | Enterobacter hormaechei strain FUJ80375 |
Toxin (Protein)
Gene name | KacT | Uniprot ID | A0A222RDD1 |
Locus tag | NGK01_RS08875 | Protein ID | WP_032647926.1 |
Coordinates | 1866800..1867321 (+) | Length | 174 a.a. |
Antitoxin (Protein)
Gene name | ataR | Uniprot ID | A0A331QJY7 |
Locus tag | NGK01_RS08870 | Protein ID | WP_015570876.1 |
Coordinates | 1866524..1866793 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NGK01_RS08835 (FJMB80375_17300) | 1862064..1862423 | + | 360 | WP_032647921.1 | helix-turn-helix domain-containing protein | - |
NGK01_RS08840 | 1862502..1862597 | - | 96 | Protein_1719 | transcriptional regulator | - |
NGK01_RS08845 (FJMB80375_17320) | 1862750..1863991 | + | 1242 | WP_032647923.1 | bifunctional glucose-1-phosphatase/inositol phosphatase | - |
NGK01_RS08850 (FJMB80375_17330) | 1864024..1864251 | - | 228 | WP_006809324.1 | YccJ family protein | - |
NGK01_RS08855 (FJMB80375_17340) | 1864270..1864866 | - | 597 | WP_006809323.1 | NAD(P)H:quinone oxidoreductase | - |
NGK01_RS08860 (FJMB80375_17350) | 1865258..1865428 | + | 171 | WP_001273664.1 | general stress protein | - |
NGK01_RS08865 (FJMB80375_17360) | 1865545..1866450 | + | 906 | WP_017693666.1 | DMT family transporter | - |
NGK01_RS08870 (FJMB80375_17370) | 1866524..1866793 | + | 270 | WP_015570876.1 | DUF1778 domain-containing protein | Antitoxin |
NGK01_RS08875 (FJMB80375_17380) | 1866800..1867321 | + | 522 | WP_032647926.1 | GNAT family N-acetyltransferase | Toxin |
NGK01_RS08880 (FJMB80375_17390) | 1867380..1868702 | - | 1323 | WP_032647928.1 | pyrimidine utilization transport protein G | - |
NGK01_RS08885 (FJMB80375_17400) | 1868724..1869215 | - | 492 | WP_032647931.1 | pyrimidine utilization flavin reductase protein F | - |
NGK01_RS08890 (FJMB80375_17410) | 1869228..1869818 | - | 591 | WP_032647932.1 | malonic semialdehyde reductase | - |
NGK01_RS08895 (FJMB80375_17420) | 1869828..1870628 | - | 801 | WP_032647935.1 | pyrimidine utilization protein D | - |
NGK01_RS08900 (FJMB80375_17430) | 1870636..1871022 | - | 387 | WP_015570870.1 | pyrimidine utilization protein C | - |
NGK01_RS08905 (FJMB80375_17440) | 1871034..1871723 | - | 690 | WP_017384771.1 | pyrimidine utilization protein B | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 174 a.a. Molecular weight: 19451.21 Da Isoelectric Point: 7.4318
>T41636 WP_032647926.1 NZ_AP025907:1866800-1867321 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA
Download Length: 522 bp
>T41636 NZ_AP025907:1866800-1867321 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGATACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTCCAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCCTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATAGAACGACTGTTTGAGCAGGCGTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10247.75 Da Isoelectric Point: 5.8836
>AT41636 WP_015570876.1 NZ_AP025907:1866524-1866793 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME
Download Length: 270 bp
>AT41636 NZ_AP025907:1866524-1866793 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGATTGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A222RDD1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A331QJY7 |