Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4083638..4084295 Replicon chromosome
Accession NZ_AP025903
Organism Enterobacter hormaechei strain FUJ80374

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag NGK42_RS19745 Protein ID WP_017382887.1
Coordinates 4083638..4084048 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGK42_RS19750 Protein ID WP_003863437.1
Coordinates 4084029..4084295 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK42_RS19725 (FJMB80374_38720) 4079636..4081369 - 1734 WP_032649421.1 single-stranded-DNA-specific exonuclease RecJ -
NGK42_RS19730 (FJMB80374_38730) 4081375..4082088 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGK42_RS19735 (FJMB80374_38740) 4082117..4083013 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGK42_RS19740 (FJMB80374_38750) 4083115..4083636 + 522 WP_032649423.1 flavodoxin FldB -
NGK42_RS19745 (FJMB80374_38760) 4083638..4084048 - 411 WP_017382887.1 protein YgfX Toxin
NGK42_RS19750 (FJMB80374_38770) 4084029..4084295 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGK42_RS19755 (FJMB80374_38780) 4084590..4085570 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGK42_RS19760 (FJMB80374_38790) 4085682..4086341 - 660 WP_003863433.1 hemolysin III family protein -
NGK42_RS19765 (FJMB80374_38800) 4086608..4087339 + 732 WP_032649427.1 MurR/RpiR family transcriptional regulator -
NGK42_RS19770 (FJMB80374_38810) 4087456..4088889 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41628 WP_017382887.1 NZ_AP025903:c4084048-4083638 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41628 NZ_AP025903:c4084048-4083638 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41628 WP_003863437.1 NZ_AP025903:c4084295-4084029 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41628 NZ_AP025903:c4084295-4084029 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References