Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2484736..2485475 Replicon chromosome
Accession NZ_AP025903
Organism Enterobacter hormaechei strain FUJ80374

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NGK42_RS11965 Protein ID WP_003857133.1
Coordinates 2484736..2485221 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK42_RS11970 Protein ID WP_003857131.1
Coordinates 2485209..2485475 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK42_RS11940 (FJMB80374_23430) 2480108..2480866 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
NGK42_RS11945 (FJMB80374_23440) 2480971..2482263 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NGK42_RS11950 (FJMB80374_23460) 2482263..2482877 + 615 WP_065420578.1 NUDIX hydrolase -
NGK42_RS11955 (FJMB80374_23470) 2483135..2484100 + 966 WP_032648329.1 hypothetical protein -
NGK42_RS11960 (FJMB80374_23480) 2484116..2484685 + 570 WP_032648331.1 hypothetical protein -
NGK42_RS11965 (FJMB80374_23490) 2484736..2485221 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NGK42_RS11970 (FJMB80374_23500) 2485209..2485475 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK42_RS11975 (FJMB80374_23510) 2485539..2486468 - 930 WP_032648334.1 LysR family transcriptional regulator -
NGK42_RS11980 (FJMB80374_23520) 2486598..2487980 + 1383 WP_032648336.1 MFS transporter -
NGK42_RS11985 (FJMB80374_23530) 2488002..2488997 - 996 WP_017382342.1 DUF2891 domain-containing protein -
NGK42_RS11990 (FJMB80374_23540) 2489007..2489993 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T41618 WP_003857133.1 NZ_AP025903:c2485221-2484736 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41618 NZ_AP025903:c2485221-2484736 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41618 WP_003857131.1 NZ_AP025903:c2485475-2485209 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41618 NZ_AP025903:c2485475-2485209 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References