41610

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4840091..4840695 Replicon chromosome
Accession NZ_AP025899
Organism Enterobacter hormaechei strain FUJ80334

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag NGJ98_RS23475 Protein ID WP_071788668.1
Coordinates 4840510..4840695 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag NGJ98_RS23470 Protein ID WP_023295606.1
Coordinates 4840091..4840495 (-) Length 135 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ98_RS23455 (FJMB80334_46060) 4835631..4836449 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
NGJ98_RS23460 (FJMB80334_46070) 4836675..4838075 + 1401 WP_017693791.1 MFS transporter -
NGJ98_RS23465 (FJMB80334_46080) 4838086..4840035 + 1950 WP_032649830.1 glycoside hydrolase family 127 protein -
NGJ98_RS23470 (FJMB80334_46090) 4840091..4840495 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NGJ98_RS23475 4840510..4840695 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
NGJ98_RS23480 (FJMB80334_46100) 4840945..4842483 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
NGJ98_RS23485 (FJMB80334_46110) 4842650..4843534 + 885 WP_003860164.1 ROK family protein -
NGJ98_RS23490 (FJMB80334_46120) 4843538..4845376 - 1839 WP_017693788.1 selenocysteine-specific translation elongation factor -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T41610 WP_071788668.1 NZ_AP025899:c4840695-4840510 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T41610 NZ_AP025899:c4840695-4840510 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT41610 WP_023295606.1 NZ_AP025899:c4840495-4840091 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT41610 NZ_AP025899:c4840495-4840091 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTCCCGGGTAGTGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2


Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References