Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4851402..4852006 Replicon chromosome
Accession NZ_AP025891
Organism Enterobacter hormaechei strain FUJ80182

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag NGJ49_RS23555 Protein ID WP_071788668.1
Coordinates 4851821..4852006 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag NGJ49_RS23550 Protein ID WP_023295606.1
Coordinates 4851402..4851806 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ49_RS23535 (FJMB80182_46300) 4846942..4847760 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
NGJ49_RS23540 (FJMB80182_46310) 4847986..4849386 + 1401 WP_017693791.1 MFS transporter -
NGJ49_RS23545 (FJMB80182_46320) 4849397..4851346 + 1950 WP_032649830.1 glycoside hydrolase family 127 protein -
NGJ49_RS23550 (FJMB80182_46330) 4851402..4851806 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NGJ49_RS23555 4851821..4852006 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
NGJ49_RS23560 (FJMB80182_46340) 4852256..4853794 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
NGJ49_RS23565 (FJMB80182_46350) 4853961..4854845 + 885 WP_003860164.1 ROK family protein -
NGJ49_RS23570 (FJMB80182_46360) 4854849..4856687 - 1839 WP_017693788.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T41572 WP_071788668.1 NZ_AP025891:c4852006-4851821 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T41572 NZ_AP025891:c4852006-4851821 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT41572 WP_023295606.1 NZ_AP025891:c4851806-4851402 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT41572 NZ_AP025891:c4851806-4851402 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTCCCGGGTAGTGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References