Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2486891..2487630 Replicon chromosome
Accession NZ_AP025891
Organism Enterobacter hormaechei strain FUJ80182

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NGJ49_RS11980 Protein ID WP_003857133.1
Coordinates 2486891..2487376 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGJ49_RS11985 Protein ID WP_003857131.1
Coordinates 2487364..2487630 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ49_RS11955 (FJMB80182_23520) 2482263..2483021 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
NGJ49_RS11960 (FJMB80182_23530) 2483126..2484418 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NGJ49_RS11965 (FJMB80182_23550) 2484418..2485032 + 615 WP_065420578.1 NUDIX hydrolase -
NGJ49_RS11970 (FJMB80182_23560) 2485290..2486255 + 966 WP_032648329.1 hypothetical protein -
NGJ49_RS11975 (FJMB80182_23570) 2486271..2486840 + 570 WP_032648331.1 hypothetical protein -
NGJ49_RS11980 (FJMB80182_23580) 2486891..2487376 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NGJ49_RS11985 (FJMB80182_23590) 2487364..2487630 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGJ49_RS11990 (FJMB80182_23600) 2487694..2488623 - 930 WP_032648334.1 LysR family transcriptional regulator -
NGJ49_RS11995 (FJMB80182_23610) 2488753..2490135 + 1383 WP_032648336.1 MFS transporter -
NGJ49_RS12000 (FJMB80182_23620) 2490157..2491152 - 996 WP_017382342.1 DUF2891 domain-containing protein -
NGJ49_RS12005 (FJMB80182_23630) 2491162..2492148 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T41561 WP_003857133.1 NZ_AP025891:c2487376-2486891 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41561 NZ_AP025891:c2487376-2486891 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41561 WP_003857131.1 NZ_AP025891:c2487630-2487364 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41561 NZ_AP025891:c2487630-2487364 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References