Detailed information of TA system TA041557

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1083558..1084273
• Replicon: chromosome
• Accession: NZ_AP025891
• Organism: Enterobacter hormaechei strain FUJ80182

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A8I0UM05
• Locus tag: NGJ49_RS05140
• Protein ID: WP_023303149.1
• Coordinates: 1083905..1084273 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A8I0UJV2
• Locus tag: NGJ49_RS05135
• Protein ID: WP_023303148.1
• Coordinates: 1083558..1083884 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NGJ49_RS05110 (FJMB80182_09970)	1078592..1079857	+	1266	WP_023303143.1	hypothetical protein	-
NGJ49_RS05115 (FJMB80182_09980)	1080166..1080600	+	435	WP_023303144.1	hypothetical protein	-
NGJ49_RS05120 (FJMB80182_09990)	1080659..1081498	+	840	WP_023303145.1	hypothetical protein	-
NGJ49_RS05125 (FJMB80182_10010)	1082188..1083009	+	822	WP_023303146.1	DUF932 domain-containing protein	-
NGJ49_RS05130 (FJMB80182_10020)	1083075..1083545	+	471	WP_023303147.1	DNA repair protein RadC	-
NGJ49_RS05135 (FJMB80182_10030)	1083558..1083884	+	327	WP_023303148.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
NGJ49_RS05140 (FJMB80182_10040)	1083905..1084273	+	369	WP_023303149.1	TA system toxin CbtA family protein	Toxin
NGJ49_RS05145 (FJMB80182_10050)	1084623..1085369	-	747	WP_032647364.1	class I SAM-dependent methyltransferase	-
NGJ49_RS05150 (FJMB80182_10060)	1085380..1085637	-	258	WP_003863178.1	YjhX family toxin	-
NGJ49_RS05155 (FJMB80182_10070)	1085897..1087834	-	1938	WP_032647366.1	bifunctional diguanylate cyclase/phosphodiesterase	-
NGJ49_RS05160 (FJMB80182_10080)	1087852..1088346	-	495	WP_023295996.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1062640..1084273	21633

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13727.91 Da
• Isoelectric Point: 8.2822

>T41557 WP_023303149.1 NZ_AP025891:1083905-1084273 [Enterobacter hormaechei]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Nucleotide

• Length: 369 bp

>T41557 NZ_AP025891:1083905-1084273 [Enterobacter hormaechei]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12215.04 Da
• Isoelectric Point: 7.0266

>AT41557 WP_023303148.1 NZ_AP025891:1083558-1083884 [Enterobacter hormaechei]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 327 bp

>AT41557 NZ_AP025891:1083558-1083884 [Enterobacter hormaechei]
ATGTCATTAATACCAGCCCATGAATGGGGGATAAAAAGCGATATTGTTCCACGGCTTGGAGTCAGATTAGTTCAGGAAGG
CAACCGGCTGCACTATCTGGCTGACCGGGCTAGTATCACCGGTAAGTTCAGTGACGCCGAATGCCTGAAGTTGGATATCG
TATTTCCGCATTTTATCCGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATTCTCGCCATGCCCACTGTGTCACT
CTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCA
ACGCTAA