41542

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2482620..2483359 Replicon chromosome
Accession NZ_AP025887
Organism Enterobacter hormaechei strain FUJ80178

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NGK69_RS11950 Protein ID WP_003857133.1
Coordinates 2482620..2483105 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK69_RS11955 Protein ID WP_003857131.1
Coordinates 2483093..2483359 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK69_RS11925 (FJMB80178_23390) 2477992..2478750 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
NGK69_RS11930 (FJMB80178_23400) 2478855..2480147 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NGK69_RS11935 (FJMB80178_23420) 2480147..2480761 + 615 WP_065420578.1 NUDIX hydrolase -
NGK69_RS11940 (FJMB80178_23430) 2481019..2481984 + 966 WP_032648329.1 hypothetical protein -
NGK69_RS11945 (FJMB80178_23440) 2482000..2482569 + 570 WP_032648331.1 hypothetical protein -
NGK69_RS11950 (FJMB80178_23450) 2482620..2483105 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NGK69_RS11955 (FJMB80178_23460) 2483093..2483359 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK69_RS11960 (FJMB80178_23470) 2483423..2484352 - 930 WP_032648334.1 LysR family transcriptional regulator -
NGK69_RS11965 (FJMB80178_23480) 2484482..2485864 + 1383 WP_032648336.1 MFS transporter -
NGK69_RS11970 (FJMB80178_23490) 2485886..2486881 - 996 WP_017382342.1 DUF2891 domain-containing protein -
NGK69_RS11975 (FJMB80178_23500) 2486891..2487877 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T41542 WP_003857133.1 NZ_AP025887:c2483105-2482620 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41542 NZ_AP025887:c2483105-2482620 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41542 WP_003857131.1 NZ_AP025887:c2483359-2483093 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41542 NZ_AP025887:c2483359-2483093 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References