41523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2440644..2441383 Replicon chromosome
Accession NZ_AP025883
Organism Enterobacter hormaechei strain FUJ80158

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NGK56_RS11660 Protein ID WP_003857133.1
Coordinates 2440644..2441129 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK56_RS11665 Protein ID WP_003857131.1
Coordinates 2441117..2441383 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK56_RS11635 (FJMB80158_22790) 2436016..2436774 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
NGK56_RS11640 (FJMB80158_22800) 2436879..2438171 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NGK56_RS11645 (FJMB80158_22820) 2438171..2438785 + 615 WP_065420578.1 NUDIX hydrolase -
NGK56_RS11650 (FJMB80158_22830) 2439043..2440008 + 966 WP_032648329.1 hypothetical protein -
NGK56_RS11655 (FJMB80158_22840) 2440024..2440593 + 570 WP_032648331.1 hypothetical protein -
NGK56_RS11660 (FJMB80158_22850) 2440644..2441129 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NGK56_RS11665 (FJMB80158_22860) 2441117..2441383 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK56_RS11670 (FJMB80158_22870) 2441447..2442376 - 930 WP_032648334.1 LysR family transcriptional regulator -
NGK56_RS11675 (FJMB80158_22880) 2442506..2443888 + 1383 WP_032648336.1 MFS transporter -
NGK56_RS11680 (FJMB80158_22890) 2443910..2444905 - 996 WP_017382342.1 DUF2891 domain-containing protein -
NGK56_RS11685 (FJMB80158_22900) 2444915..2445901 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T41523 WP_003857133.1 NZ_AP025883:c2441129-2440644 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41523 NZ_AP025883:c2441129-2440644 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41523 WP_003857131.1 NZ_AP025883:c2441383-2441117 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41523 NZ_AP025883:c2441383-2441117 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References