Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4085267..4085924 Replicon chromosome
Accession NZ_AP025871
Organism Enterobacter hormaechei strain FUJ80152

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag NGJ83_RS19755 Protein ID WP_017382887.1
Coordinates 4085267..4085677 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGJ83_RS19760 Protein ID WP_003863437.1
Coordinates 4085658..4085924 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ83_RS19735 (FJMB80152_38700) 4081265..4082998 - 1734 WP_032649421.1 single-stranded-DNA-specific exonuclease RecJ -
NGJ83_RS19740 (FJMB80152_38710) 4083004..4083717 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGJ83_RS19745 (FJMB80152_38720) 4083746..4084642 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGJ83_RS19750 (FJMB80152_38730) 4084744..4085265 + 522 WP_032649423.1 flavodoxin FldB -
NGJ83_RS19755 (FJMB80152_38740) 4085267..4085677 - 411 WP_017382887.1 protein YgfX Toxin
NGJ83_RS19760 (FJMB80152_38750) 4085658..4085924 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGJ83_RS19765 (FJMB80152_38760) 4086219..4087199 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGJ83_RS19770 (FJMB80152_38770) 4087311..4087970 - 660 WP_003863433.1 hemolysin III family protein -
NGJ83_RS19775 (FJMB80152_38780) 4088237..4088968 + 732 WP_032649427.1 MurR/RpiR family transcriptional regulator -
NGJ83_RS19780 (FJMB80152_38790) 4089085..4090518 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41476 WP_017382887.1 NZ_AP025871:c4085677-4085267 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41476 NZ_AP025871:c4085677-4085267 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41476 WP_003863437.1 NZ_AP025871:c4085924-4085658 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41476 NZ_AP025871:c4085924-4085658 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References