Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4839189..4839793 Replicon chromosome
Accession NZ_AP025863
Organism Enterobacter hormaechei strain FUJ80146

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag NGJ48_RS23460 Protein ID WP_071788668.1
Coordinates 4839608..4839793 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag NGJ48_RS23455 Protein ID WP_023295606.1
Coordinates 4839189..4839593 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ48_RS23440 (FJMB80146_46090) 4834729..4835547 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
NGJ48_RS23445 (FJMB80146_46100) 4835773..4837173 + 1401 WP_017693791.1 MFS transporter -
NGJ48_RS23450 (FJMB80146_46110) 4837184..4839133 + 1950 WP_032649830.1 glycoside hydrolase family 127 protein -
NGJ48_RS23455 (FJMB80146_46120) 4839189..4839593 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NGJ48_RS23460 4839608..4839793 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
NGJ48_RS23465 (FJMB80146_46130) 4840043..4841581 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
NGJ48_RS23470 (FJMB80146_46140) 4841748..4842632 + 885 WP_003860164.1 ROK family protein -
NGJ48_RS23475 (FJMB80146_46150) 4842636..4844474 - 1839 WP_017693788.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T41440 WP_071788668.1 NZ_AP025863:c4839793-4839608 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T41440 NZ_AP025863:c4839793-4839608 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT41440 WP_023295606.1 NZ_AP025863:c4839593-4839189 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT41440 NZ_AP025863:c4839593-4839189 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTCCCGGGTAGTGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References