Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4082867..4083524 Replicon chromosome
Accession NZ_AP025859
Organism Enterobacter hormaechei strain FUJ80145

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag NGJ45_RS19735 Protein ID WP_017382887.1
Coordinates 4082867..4083277 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGJ45_RS19740 Protein ID WP_003863437.1
Coordinates 4083258..4083524 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ45_RS19715 (FJMB80145_38620) 4078865..4080598 - 1734 WP_032649421.1 single-stranded-DNA-specific exonuclease RecJ -
NGJ45_RS19720 (FJMB80145_38630) 4080604..4081317 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGJ45_RS19725 (FJMB80145_38640) 4081346..4082242 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGJ45_RS19730 (FJMB80145_38650) 4082344..4082865 + 522 WP_032649423.1 flavodoxin FldB -
NGJ45_RS19735 (FJMB80145_38660) 4082867..4083277 - 411 WP_017382887.1 protein YgfX Toxin
NGJ45_RS19740 (FJMB80145_38670) 4083258..4083524 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGJ45_RS19745 (FJMB80145_38680) 4083819..4084799 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGJ45_RS19750 (FJMB80145_38690) 4084911..4085570 - 660 WP_003863433.1 hemolysin III family protein -
NGJ45_RS19755 (FJMB80145_38700) 4085837..4086568 + 732 WP_032649427.1 MurR/RpiR family transcriptional regulator -
NGJ45_RS19760 (FJMB80145_38710) 4086685..4088118 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41420 WP_017382887.1 NZ_AP025859:c4083277-4082867 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41420 NZ_AP025859:c4083277-4082867 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41420 WP_003863437.1 NZ_AP025859:c4083524-4083258 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41420 NZ_AP025859:c4083524-4083258 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References