Detailed information of TA system TA041406

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1082609..1083324
• Replicon: chromosome
• Accession: NZ_AP025859
• Organism: Enterobacter hormaechei strain FUJ80145

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A8I0UM05
• Locus tag: NGJ45_RS05125
• Protein ID: WP_023303149.1
• Coordinates: 1082956..1083324 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A8I0UJV2
• Locus tag: NGJ45_RS05120
• Protein ID: WP_023303148.1
• Coordinates: 1082609..1082935 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NGJ45_RS05095 (FJMB80145_09910)	1077643..1078908	+	1266	WP_023303143.1	hypothetical protein	-
NGJ45_RS05100 (FJMB80145_09920)	1079217..1079651	+	435	WP_023303144.1	hypothetical protein	-
NGJ45_RS05105 (FJMB80145_09930)	1079710..1080549	+	840	WP_023303145.1	hypothetical protein	-
NGJ45_RS05110 (FJMB80145_09950)	1081239..1082060	+	822	WP_023303146.1	DUF932 domain-containing protein	-
NGJ45_RS05115 (FJMB80145_09960)	1082126..1082596	+	471	WP_023303147.1	DNA repair protein RadC	-
NGJ45_RS05120 (FJMB80145_09970)	1082609..1082935	+	327	WP_023303148.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
NGJ45_RS05125 (FJMB80145_09980)	1082956..1083324	+	369	WP_023303149.1	TA system toxin CbtA family protein	Toxin
NGJ45_RS05130 (FJMB80145_09990)	1083674..1084420	-	747	WP_032647364.1	class I SAM-dependent methyltransferase	-
NGJ45_RS05135 (FJMB80145_10000)	1084431..1084688	-	258	WP_003863178.1	YjhX family toxin	-
NGJ45_RS05140 (FJMB80145_10010)	1084948..1086885	-	1938	WP_032647366.1	bifunctional diguanylate cyclase/phosphodiesterase	-
NGJ45_RS05145 (FJMB80145_10020)	1086903..1087397	-	495	WP_023295996.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1061691..1083324	21633

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13727.91 Da
• Isoelectric Point: 8.2822

>T41406 WP_023303149.1 NZ_AP025859:1082956-1083324 [Enterobacter hormaechei]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Nucleotide

• Length: 369 bp

>T41406 NZ_AP025859:1082956-1083324 [Enterobacter hormaechei]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12215.04 Da
• Isoelectric Point: 7.0266

>AT41406 WP_023303148.1 NZ_AP025859:1082609-1082935 [Enterobacter hormaechei]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 327 bp

>AT41406 NZ_AP025859:1082609-1082935 [Enterobacter hormaechei]
ATGTCATTAATACCAGCCCATGAATGGGGGATAAAAAGCGATATTGTTCCACGGCTTGGAGTCAGATTAGTTCAGGAAGG
CAACCGGCTGCACTATCTGGCTGACCGGGCTAGTATCACCGGTAAGTTCAGTGACGCCGAATGCCTGAAGTTGGATATCG
TATTTCCGCATTTTATCCGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATTCTCGCCATGCCCACTGTGTCACT
CTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCA
ACGCTAA