Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1082609..1083324 Replicon chromosome
Accession NZ_AP025859
Organism Enterobacter hormaechei strain FUJ80145

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8I0UM05
Locus tag NGJ45_RS05125 Protein ID WP_023303149.1
Coordinates 1082956..1083324 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8I0UJV2
Locus tag NGJ45_RS05120 Protein ID WP_023303148.1
Coordinates 1082609..1082935 (+) Length 109 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ45_RS05095 (FJMB80145_09910) 1077643..1078908 + 1266 WP_023303143.1 hypothetical protein -
NGJ45_RS05100 (FJMB80145_09920) 1079217..1079651 + 435 WP_023303144.1 hypothetical protein -
NGJ45_RS05105 (FJMB80145_09930) 1079710..1080549 + 840 WP_023303145.1 hypothetical protein -
NGJ45_RS05110 (FJMB80145_09950) 1081239..1082060 + 822 WP_023303146.1 DUF932 domain-containing protein -
NGJ45_RS05115 (FJMB80145_09960) 1082126..1082596 + 471 WP_023303147.1 DNA repair protein RadC -
NGJ45_RS05120 (FJMB80145_09970) 1082609..1082935 + 327 WP_023303148.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NGJ45_RS05125 (FJMB80145_09980) 1082956..1083324 + 369 WP_023303149.1 TA system toxin CbtA family protein Toxin
NGJ45_RS05130 (FJMB80145_09990) 1083674..1084420 - 747 WP_032647364.1 class I SAM-dependent methyltransferase -
NGJ45_RS05135 (FJMB80145_10000) 1084431..1084688 - 258 WP_003863178.1 YjhX family toxin -
NGJ45_RS05140 (FJMB80145_10010) 1084948..1086885 - 1938 WP_032647366.1 bifunctional diguanylate cyclase/phosphodiesterase -
NGJ45_RS05145 (FJMB80145_10020) 1086903..1087397 - 495 WP_023295996.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1061691..1083324 21633


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-111)

Antitoxin

(7-107)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13727.91 Da        Isoelectric Point: 8.2822

>T41406 WP_023303149.1 NZ_AP025859:1082956-1083324 [Enterobacter hormaechei]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Download         Length: 369 bp

>T41406 NZ_AP025859:1082956-1083324 [Enterobacter hormaechei]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12215.04 Da        Isoelectric Point: 7.0266

>AT41406 WP_023303148.1 NZ_AP025859:1082609-1082935 [Enterobacter hormaechei]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 327 bp

>AT41406 NZ_AP025859:1082609-1082935 [Enterobacter hormaechei]
ATGTCATTAATACCAGCCCATGAATGGGGGATAAAAAGCGATATTGTTCCACGGCTTGGAGTCAGATTAGTTCAGGAAGG
CAACCGGCTGCACTATCTGGCTGACCGGGCTAGTATCACCGGTAAGTTCAGTGACGCCGAATGCCTGAAGTTGGATATCG
TATTTCCGCATTTTATCCGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATTCTCGCCATGCCCACTGTGTCACT
CTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCA
ACGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References