Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4838415..4839019 Replicon chromosome
Accession NZ_AP025855
Organism Enterobacter hormaechei strain FUJ80144

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag NGJ60_RS23455 Protein ID WP_071788668.1
Coordinates 4838834..4839019 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag NGJ60_RS23450 Protein ID WP_023295606.1
Coordinates 4838415..4838819 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ60_RS23435 (FJMB80144_45990) 4833955..4834773 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
NGJ60_RS23440 (FJMB80144_46000) 4834999..4836399 + 1401 WP_017693791.1 MFS transporter -
NGJ60_RS23445 (FJMB80144_46010) 4836410..4838359 + 1950 WP_032649830.1 glycoside hydrolase family 127 protein -
NGJ60_RS23450 (FJMB80144_46020) 4838415..4838819 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NGJ60_RS23455 4838834..4839019 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
NGJ60_RS23460 (FJMB80144_46030) 4839269..4840807 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
NGJ60_RS23465 (FJMB80144_46040) 4840974..4841858 + 885 WP_003860164.1 ROK family protein -
NGJ60_RS23470 (FJMB80144_46050) 4841862..4843700 - 1839 WP_017693788.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T41402 WP_071788668.1 NZ_AP025855:c4839019-4838834 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T41402 NZ_AP025855:c4839019-4838834 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT41402 WP_023295606.1 NZ_AP025855:c4838819-4838415 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT41402 NZ_AP025855:c4838819-4838415 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTCCCGGGTAGTGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References