Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2482624..2483363 Replicon chromosome
Accession NZ_AP025855
Organism Enterobacter hormaechei strain FUJ80144

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag NGJ60_RS11945 Protein ID WP_003857133.1
Coordinates 2482624..2483109 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGJ60_RS11950 Protein ID WP_003857131.1
Coordinates 2483097..2483363 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ60_RS11920 (FJMB80144_23350) 2477996..2478754 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
NGJ60_RS11925 (FJMB80144_23360) 2478859..2480151 + 1293 WP_032648327.1 glycosyl hydrolase family 28 protein -
NGJ60_RS11930 (FJMB80144_23380) 2480151..2480765 + 615 WP_065420578.1 NUDIX hydrolase -
NGJ60_RS11935 (FJMB80144_23390) 2481023..2481988 + 966 WP_032648329.1 hypothetical protein -
NGJ60_RS11940 (FJMB80144_23400) 2482004..2482573 + 570 WP_032648331.1 hypothetical protein -
NGJ60_RS11945 (FJMB80144_23410) 2482624..2483109 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
NGJ60_RS11950 (FJMB80144_23420) 2483097..2483363 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGJ60_RS11955 (FJMB80144_23430) 2483427..2484356 - 930 WP_032648334.1 LysR family transcriptional regulator -
NGJ60_RS11960 (FJMB80144_23440) 2484486..2485868 + 1383 WP_032648336.1 MFS transporter -
NGJ60_RS11965 (FJMB80144_23450) 2485890..2486885 - 996 WP_017382342.1 DUF2891 domain-containing protein -
NGJ60_RS11970 (FJMB80144_23460) 2486895..2487881 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T41391 WP_003857133.1 NZ_AP025855:c2483109-2482624 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41391 NZ_AP025855:c2483109-2482624 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGTGTAGCAGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41391 WP_003857131.1 NZ_AP025855:c2483363-2483097 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41391 NZ_AP025855:c2483363-2483097 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References