Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4018112..4018769 Replicon chromosome
Accession NZ_AP025851
Organism Enterobacter hormaechei strain FUJ80068

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag NGJ26_RS19240 Protein ID WP_017382887.1
Coordinates 4018112..4018522 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGJ26_RS19245 Protein ID WP_003863437.1
Coordinates 4018503..4018769 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ26_RS19220 (FJMB80068_37770) 4014110..4015843 - 1734 WP_032649421.1 single-stranded-DNA-specific exonuclease RecJ -
NGJ26_RS19225 (FJMB80068_37780) 4015849..4016562 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGJ26_RS19230 (FJMB80068_37790) 4016591..4017487 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGJ26_RS19235 (FJMB80068_37800) 4017589..4018110 + 522 WP_032649423.1 flavodoxin FldB -
NGJ26_RS19240 (FJMB80068_37810) 4018112..4018522 - 411 WP_017382887.1 protein YgfX Toxin
NGJ26_RS19245 (FJMB80068_37820) 4018503..4018769 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGJ26_RS19250 (FJMB80068_37830) 4019064..4020044 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGJ26_RS19255 (FJMB80068_37840) 4020156..4020815 - 660 WP_003863433.1 hemolysin III family protein -
NGJ26_RS19260 (FJMB80068_37850) 4021082..4021813 + 732 WP_032649427.1 MurR/RpiR family transcriptional regulator -
NGJ26_RS19265 (FJMB80068_37860) 4021930..4023363 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41382 WP_017382887.1 NZ_AP025851:c4018522-4018112 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41382 NZ_AP025851:c4018522-4018112 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41382 WP_003863437.1 NZ_AP025851:c4018769-4018503 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41382 NZ_AP025851:c4018769-4018503 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References