Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4061155..4061812 Replicon chromosome
Accession NZ_AP025847
Organism Enterobacter hormaechei strain FUJ80063

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag NGK57_RS19540 Protein ID WP_017382887.1
Coordinates 4061155..4061565 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGK57_RS19545 Protein ID WP_003863437.1
Coordinates 4061546..4061812 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK57_RS19520 (FJMB80063_38390) 4057153..4058886 - 1734 WP_032649421.1 single-stranded-DNA-specific exonuclease RecJ -
NGK57_RS19525 (FJMB80063_38400) 4058892..4059605 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGK57_RS19530 (FJMB80063_38410) 4059634..4060530 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGK57_RS19535 (FJMB80063_38420) 4060632..4061153 + 522 WP_032649423.1 flavodoxin FldB -
NGK57_RS19540 (FJMB80063_38430) 4061155..4061565 - 411 WP_017382887.1 protein YgfX Toxin
NGK57_RS19545 (FJMB80063_38440) 4061546..4061812 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGK57_RS19550 (FJMB80063_38450) 4062107..4063087 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGK57_RS19555 (FJMB80063_38460) 4063199..4063858 - 660 WP_003863433.1 hemolysin III family protein -
NGK57_RS19560 (FJMB80063_38470) 4064125..4064856 + 732 WP_032649427.1 MurR/RpiR family transcriptional regulator -
NGK57_RS19565 (FJMB80063_38480) 4064973..4066406 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41363 WP_017382887.1 NZ_AP025847:c4061565-4061155 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41363 NZ_AP025847:c4061565-4061155 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41363 WP_003863437.1 NZ_AP025847:c4061812-4061546 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41363 NZ_AP025847:c4061812-4061546 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References