Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1091611..1092326 Replicon chromosome
Accession NZ_AP025847
Organism Enterobacter hormaechei strain FUJ80063

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8I0UM05
Locus tag NGK57_RS05175 Protein ID WP_023303149.1
Coordinates 1091958..1092326 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8I0UJV2
Locus tag NGK57_RS05170 Protein ID WP_023303148.1
Coordinates 1091611..1091937 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK57_RS05145 (FJMB80063_10050) 1086645..1087910 + 1266 WP_023303143.1 hypothetical protein -
NGK57_RS05150 (FJMB80063_10060) 1088219..1088653 + 435 WP_023303144.1 hypothetical protein -
NGK57_RS05155 (FJMB80063_10070) 1088712..1089551 + 840 WP_023303145.1 hypothetical protein -
NGK57_RS05160 (FJMB80063_10090) 1090241..1091062 + 822 WP_023303146.1 DUF932 domain-containing protein -
NGK57_RS05165 (FJMB80063_10100) 1091128..1091598 + 471 WP_023303147.1 DNA repair protein RadC -
NGK57_RS05170 (FJMB80063_10110) 1091611..1091937 + 327 WP_023303148.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NGK57_RS05175 (FJMB80063_10120) 1091958..1092326 + 369 WP_023303149.1 TA system toxin CbtA family protein Toxin
NGK57_RS05180 (FJMB80063_10130) 1092676..1093422 - 747 WP_032647364.1 class I SAM-dependent methyltransferase -
NGK57_RS05185 (FJMB80063_10140) 1093433..1093690 - 258 WP_003863178.1 YjhX family toxin -
NGK57_RS05190 (FJMB80063_10150) 1093950..1095887 - 1938 WP_032647366.1 bifunctional diguanylate cyclase/phosphodiesterase -
NGK57_RS05195 (FJMB80063_10160) 1095905..1096399 - 495 WP_023295996.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13727.91 Da        Isoelectric Point: 8.2822

>T41349 WP_023303149.1 NZ_AP025847:1091958-1092326 [Enterobacter hormaechei]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Download         Length: 369 bp

>T41349 NZ_AP025847:1091958-1092326 [Enterobacter hormaechei]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12215.04 Da        Isoelectric Point: 7.0266

>AT41349 WP_023303148.1 NZ_AP025847:1091611-1091937 [Enterobacter hormaechei]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 327 bp

>AT41349 NZ_AP025847:1091611-1091937 [Enterobacter hormaechei]
ATGTCATTAATACCAGCCCATGAATGGGGGATAAAAAGCGATATTGTTCCACGGCTTGGAGTCAGATTAGTTCAGGAAGG
CAACCGGCTGCACTATCTGGCTGACCGGGCTAGTATCACCGGTAAGTTCAGTGACGCCGAATGCCTGAAGTTGGATATCG
TATTTCCGCATTTTATCCGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATTCTCGCCATGCCCACTGTGTCACT
CTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCA
ACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References