Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2393768..2394507 Replicon chromosome
Accession NZ_AP025842
Organism Enterobacter hormaechei strain FUJ80379

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NMC33_RS11535 Protein ID WP_022648141.1
Coordinates 2394022..2394507 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NMC33_RS11530 Protein ID WP_003857131.1
Coordinates 2393768..2394034 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMC33_RS11505 (FJMB80379_22450) 2388862..2389440 + 579 WP_022648146.1 fimbrial protein -
NMC33_RS11510 (FJMB80379_22460) 2389464..2390600 + 1137 WP_022648145.1 type 1 fimbrial protein -
NMC33_RS11515 (FJMB80379_22470) 2390721..2391278 + 558 WP_022648144.1 OmpH family outer membrane protein -
NMC33_RS11520 (FJMB80379_22480) 2391257..2392645 - 1389 WP_022648143.1 MFS transporter -
NMC33_RS11525 (FJMB80379_22490) 2392775..2393704 + 930 WP_022648142.1 LysR family transcriptional regulator -
NMC33_RS11530 (FJMB80379_22500) 2393768..2394034 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NMC33_RS11535 (FJMB80379_22510) 2394022..2394507 + 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NMC33_RS11540 (FJMB80379_22520) 2394533..2395102 - 570 WP_022648140.1 hypothetical protein -
NMC33_RS11545 (FJMB80379_22530) 2395235..2395564 + 330 WP_022648139.1 hypothetical protein -
NMC33_RS11550 (FJMB80379_22540) 2395539..2395802 - 264 WP_022648138.1 DUF4225 domain-containing protein -
NMC33_RS11555 (FJMB80379_22550) 2396469..2397233 - 765 WP_023300126.1 SDR family NAD(P)-dependent oxidoreductase -
NMC33_RS11560 (FJMB80379_22560) 2397329..2398351 - 1023 WP_022648135.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T41343 WP_022648141.1 NZ_AP025842:2394022-2394507 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41343 NZ_AP025842:2394022-2394507 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41343 WP_003857131.1 NZ_AP025842:2393768-2394034 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41343 NZ_AP025842:2393768-2394034 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References