Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 879629..880286 Replicon chromosome
Accession NZ_AP025842
Organism Enterobacter hormaechei strain FUJ80379

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag NMC33_RS04325 Protein ID WP_022649305.1
Coordinates 879876..880286 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NMC33_RS04320 Protein ID WP_003863437.1
Coordinates 879629..879895 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMC33_RS04305 (FJMB80379_08350) 876173..876904 - 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -
NMC33_RS04310 (FJMB80379_08360) 877171..877830 + 660 WP_022649307.1 hemolysin III family protein -
NMC33_RS04315 (FJMB80379_08380) 878354..879334 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NMC33_RS04320 (FJMB80379_08390) 879629..879895 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NMC33_RS04325 (FJMB80379_08400) 879876..880286 + 411 WP_022649305.1 protein YgfX Toxin
NMC33_RS04330 (FJMB80379_08410) 880288..880809 - 522 WP_015571793.1 flavodoxin FldB -
NMC33_RS04335 (FJMB80379_08420) 880911..881807 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NMC33_RS04340 (FJMB80379_08430) 881836..882549 + 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NMC33_RS04345 (FJMB80379_08440) 882555..884288 + 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41336 WP_022649305.1 NZ_AP025842:879876-880286 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41336 NZ_AP025842:879876-880286 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41336 WP_003863437.1 NZ_AP025842:879629-879895 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41336 NZ_AP025842:879629-879895 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References