Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3495403..3496142 Replicon chromosome
Accession NZ_AP025836
Organism Enterobacter hormaechei strain FUJ80199

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag NMC34_RS16775 Protein ID WP_022649088.1
Coordinates 3495762..3496142 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag NMC34_RS16770 Protein ID WP_022649087.1
Coordinates 3495403..3495729 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMC34_RS16755 (FJMB80199_32840) 3491297..3493957 - 2661 WP_022649084.1 antiviral RADAR system adenosine triphosphatase RdrA -
NMC34_RS16760 (FJMB80199_32850) 3494587..3494910 + 324 WP_022649085.1 antirestriction protein -
NMC34_RS16765 (FJMB80199_32860) 3494925..3495392 + 468 WP_022649086.1 DNA repair protein RadC -
NMC34_RS16770 (FJMB80199_32870) 3495403..3495729 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NMC34_RS16775 (FJMB80199_32880) 3495762..3496142 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
NMC34_RS16780 (FJMB80199_32890) 3496139..3496366 + 228 WP_022649089.1 DUF5983 family protein -
NMC34_RS16785 (FJMB80199_32900) 3496758..3497051 + 294 WP_022649090.1 contact-dependent growth inhibition system immunity protein -
NMC34_RS16790 (FJMB80199_32910) 3497395..3498711 - 1317 WP_022649091.1 amidase family protein -
NMC34_RS16795 (FJMB80199_32920) 3498766..3500061 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3472294..3497051 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T41313 WP_022649088.1 NZ_AP025836:3495762-3496142 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T41313 NZ_AP025836:3495762-3496142 [Enterobacter hormaechei]
ATGCAAACTTTACCGTTACCCGAACCTCGGGCGGCTGAGCCATGTCCGTCGCCCGTGCAGGTCTGGCAACTCCTGCTCAC
GCATCTGCTGGATAAGCATTATGGTCTCACACTCAATGACACGCCGTTTGGCGACGACGGCGTAATTCAGGCGCACATCA
ACGCCGGTATCTCTCTGTGCGACGCCGTCAACTTCATTGTGGAAAGGTATGAACTGTTGCGCACTGACCACAGCAGCTCC
AGCCTCACCGAGCACTCTTCACTGATTGGTGCCATCGACATCCTGCGTGCCCACCGTGCAACCGGCCTGATAGTGGGCAG
CGGCTACAGCACCATCACCCGCATCACAACGGGCCAGTATCGGGAGGACAAAACACAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT41313 WP_022649087.1 NZ_AP025836:3495403-3495729 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT41313 NZ_AP025836:3495403-3495729 [Enterobacter hormaechei]
ATGCATTCTGAACAATGGGGACTGACGTGCGGTAAAACGCCGTGCTTCAGTGCCAAGCTGGTGCAGGAAGGCAACCGGCT
GCACTTTCTAGCTGACCGAGCAGAGTTTAGTGGCGACTTGAGCGACGATGAGGCACTGCGCCTCGACCAGGCTTTTCCGG
TGATATTGAAGCAGCTGGAACAAATGCTTTCAGCCGGTGAGCTGAATCCCCGCCATCAGCATCGCGTCACTCTGCATCTT
AACGGGCTAACCTGCGAAGCCGACACGCTCGGTTCGCACGGCTACCTTTACATCGCGATTTATCCCTCAGCGGTAGCTAC
CGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References