Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2280973..2281712 Replicon chromosome
Accession NZ_AP025836
Organism Enterobacter hormaechei strain FUJ80199

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NMC34_RS11070 Protein ID WP_022648141.1
Coordinates 2280973..2281458 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NMC34_RS11075 Protein ID WP_003857131.1
Coordinates 2281446..2281712 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMC34_RS11040 2276499..2277707 + 1209 WP_001339197.1 IS4-like element ISVsa5 family transposase -
NMC34_RS11045 (FJMB80199_21600) 2277720..2278151 + 432 WP_251259014.1 alpha/beta hydrolase -
NMC34_RS11050 (FJMB80199_21610) 2278247..2279011 + 765 WP_022648136.1 SDR family oxidoreductase -
NMC34_RS11055 (FJMB80199_21630) 2279678..2279941 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NMC34_RS11060 (FJMB80199_21640) 2279916..2280245 - 330 WP_022648139.1 hypothetical protein -
NMC34_RS11065 (FJMB80199_21650) 2280378..2280947 + 570 WP_022648140.1 hypothetical protein -
NMC34_RS11070 (FJMB80199_21660) 2280973..2281458 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NMC34_RS11075 (FJMB80199_21670) 2281446..2281712 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NMC34_RS11080 (FJMB80199_21680) 2281776..2282705 - 930 WP_022648142.1 LysR family transcriptional regulator -
NMC34_RS11085 (FJMB80199_21690) 2282835..2284223 + 1389 WP_022648143.1 MFS transporter -
NMC34_RS11090 (FJMB80199_21700) 2284202..2284759 - 558 WP_022648144.1 OmpH family outer membrane protein -
NMC34_RS11095 (FJMB80199_21710) 2284880..2286016 - 1137 WP_022648145.1 type 1 fimbrial protein -
NMC34_RS11100 (FJMB80199_21720) 2286040..2286618 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2256768..2281712 24944
- flank IS/Tn - - 2276499..2277707 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T41304 WP_022648141.1 NZ_AP025836:c2281458-2280973 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41304 NZ_AP025836:c2281458-2280973 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41304 WP_003857131.1 NZ_AP025836:c2281712-2281446 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41304 NZ_AP025836:c2281712-2281446 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References