Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2294042..2294781 Replicon chromosome
Accession NZ_AP025824
Organism Enterobacter hormaechei strain FUJ80067

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGJ94_RS11065 Protein ID WP_022648141.1
Coordinates 2294042..2294527 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGJ94_RS11070 Protein ID WP_003857131.1
Coordinates 2294515..2294781 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ94_RS11040 (FJMB80067_21800) 2290198..2291220 + 1023 WP_022648135.1 alpha/beta hydrolase -
NGJ94_RS11045 (FJMB80067_21810) 2291316..2292080 + 765 WP_022648136.1 SDR family oxidoreductase -
NGJ94_RS11050 (FJMB80067_21830) 2292747..2293010 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGJ94_RS11055 (FJMB80067_21840) 2292985..2293314 - 330 WP_022648139.1 hypothetical protein -
NGJ94_RS11060 (FJMB80067_21850) 2293447..2294016 + 570 WP_022648140.1 hypothetical protein -
NGJ94_RS11065 (FJMB80067_21860) 2294042..2294527 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGJ94_RS11070 (FJMB80067_21870) 2294515..2294781 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGJ94_RS11075 (FJMB80067_21880) 2294845..2295774 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGJ94_RS11080 (FJMB80067_21890) 2295904..2297292 + 1389 WP_022648143.1 MFS transporter -
NGJ94_RS11085 (FJMB80067_21900) 2297271..2297828 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGJ94_RS11090 (FJMB80067_21910) 2297949..2299085 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGJ94_RS11095 (FJMB80067_21920) 2299109..2299687 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2271175..2294781 23606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T41241 WP_022648141.1 NZ_AP025824:c2294527-2294042 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41241 NZ_AP025824:c2294527-2294042 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41241 WP_003857131.1 NZ_AP025824:c2294781-2294515 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41241 NZ_AP025824:c2294781-2294515 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References