Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3719448..3720105 Replicon chromosome
Accession NZ_AP025818
Organism Enterobacter hormaechei strain FUJ80065

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag NGJ50_RS17630 Protein ID WP_022649305.1
Coordinates 3719448..3719858 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGJ50_RS17635 Protein ID WP_003863437.1
Coordinates 3719839..3720105 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ50_RS17610 (FJMB80065_34320) 3715446..3717179 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
NGJ50_RS17615 (FJMB80065_34330) 3717185..3717898 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGJ50_RS17620 (FJMB80065_34340) 3717927..3718823 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGJ50_RS17625 (FJMB80065_34350) 3718925..3719446 + 522 WP_015571793.1 flavodoxin FldB -
NGJ50_RS17630 (FJMB80065_34360) 3719448..3719858 - 411 WP_022649305.1 protein YgfX Toxin
NGJ50_RS17635 (FJMB80065_34370) 3719839..3720105 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGJ50_RS17640 (FJMB80065_34380) 3720400..3721380 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGJ50_RS17645 (FJMB80065_34400) 3721904..3722563 - 660 WP_022649307.1 hemolysin III family protein -
NGJ50_RS17650 (FJMB80065_34410) 3722830..3723561 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41219 WP_022649305.1 NZ_AP025818:c3719858-3719448 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41219 NZ_AP025818:c3719858-3719448 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41219 WP_003863437.1 NZ_AP025818:c3720105-3719839 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41219 NZ_AP025818:c3720105-3719839 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References