Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2220934..2221673 Replicon chromosome
Accession NZ_AP025818
Organism Enterobacter hormaechei strain FUJ80065

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGJ50_RS10530 Protein ID WP_022648141.1
Coordinates 2220934..2221419 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGJ50_RS10535 Protein ID WP_003857131.1
Coordinates 2221407..2221673 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ50_RS10505 (FJMB80065_20450) 2217090..2218112 + 1023 WP_022648135.1 alpha/beta hydrolase -
NGJ50_RS10510 (FJMB80065_20460) 2218208..2218972 + 765 WP_023300126.1 SDR family NAD(P)-dependent oxidoreductase -
NGJ50_RS10515 (FJMB80065_20480) 2219639..2219902 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGJ50_RS10520 (FJMB80065_20490) 2219877..2220206 - 330 WP_022648139.1 hypothetical protein -
NGJ50_RS10525 (FJMB80065_20500) 2220339..2220908 + 570 WP_022648140.1 hypothetical protein -
NGJ50_RS10530 (FJMB80065_20510) 2220934..2221419 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGJ50_RS10535 (FJMB80065_20520) 2221407..2221673 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGJ50_RS10540 (FJMB80065_20530) 2221737..2222666 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGJ50_RS10545 (FJMB80065_20540) 2222796..2224184 + 1389 WP_022648143.1 MFS transporter -
NGJ50_RS10550 (FJMB80065_20550) 2224163..2224720 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGJ50_RS10555 (FJMB80065_20560) 2224841..2225977 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGJ50_RS10560 (FJMB80065_20570) 2226001..2226579 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2198067..2224720 26653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T41209 WP_022648141.1 NZ_AP025818:c2221419-2220934 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41209 NZ_AP025818:c2221419-2220934 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41209 WP_003857131.1 NZ_AP025818:c2221673-2221407 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41209 NZ_AP025818:c2221673-2221407 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References