Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3728605..3729262 Replicon chromosome
Accession NZ_AP025815
Organism Enterobacter hormaechei strain FUJ80064

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag NGJ20_RS17680 Protein ID WP_022649305.1
Coordinates 3728605..3729015 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGJ20_RS17685 Protein ID WP_003863437.1
Coordinates 3728996..3729262 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ20_RS17660 (FJMB80064_34400) 3724603..3726336 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
NGJ20_RS17665 (FJMB80064_34410) 3726342..3727055 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGJ20_RS17670 (FJMB80064_34420) 3727084..3727980 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGJ20_RS17675 (FJMB80064_34430) 3728082..3728603 + 522 WP_015571793.1 flavodoxin FldB -
NGJ20_RS17680 (FJMB80064_34440) 3728605..3729015 - 411 WP_022649305.1 protein YgfX Toxin
NGJ20_RS17685 (FJMB80064_34450) 3728996..3729262 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGJ20_RS17690 (FJMB80064_34460) 3729557..3730537 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGJ20_RS17695 (FJMB80064_34480) 3731061..3731720 - 660 WP_022649307.1 hemolysin III family protein -
NGJ20_RS17700 (FJMB80064_34490) 3731987..3732718 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41203 WP_022649305.1 NZ_AP025815:c3729015-3728605 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41203 NZ_AP025815:c3729015-3728605 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41203 WP_003863437.1 NZ_AP025815:c3729262-3728996 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41203 NZ_AP025815:c3729262-3728996 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References