Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3514447..3515186 Replicon chromosome
Accession NZ_AP025810
Organism Enterobacter hormaechei strain FUJ80060

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag NGJ58_RS16815 Protein ID WP_022649088.1
Coordinates 3514806..3515186 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag NGJ58_RS16810 Protein ID WP_022649087.1
Coordinates 3514447..3514773 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ58_RS16795 (FJMB80060_33000) 3510341..3513001 - 2661 WP_022649084.1 antiviral RADAR system adenosine triphosphatase RdrA -
NGJ58_RS16800 (FJMB80060_33010) 3513631..3513954 + 324 WP_022649085.1 antirestriction protein -
NGJ58_RS16805 (FJMB80060_33020) 3513969..3514436 + 468 WP_022649086.1 DNA repair protein RadC -
NGJ58_RS16810 (FJMB80060_33030) 3514447..3514773 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NGJ58_RS16815 (FJMB80060_33040) 3514806..3515186 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
NGJ58_RS16820 (FJMB80060_33050) 3515183..3515410 + 228 WP_022649089.1 DUF5983 family protein -
NGJ58_RS16825 (FJMB80060_33060) 3515802..3516095 + 294 WP_022649090.1 contact-dependent growth inhibition system immunity protein -
NGJ58_RS16830 (FJMB80060_33070) 3516439..3517755 - 1317 WP_022649091.1 amidase family protein -
NGJ58_RS16835 (FJMB80060_33080) 3517810..3519105 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3491338..3516095 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T41170 WP_022649088.1 NZ_AP025810:3514806-3515186 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T41170 NZ_AP025810:3514806-3515186 [Enterobacter hormaechei]
ATGCAAACTTTACCGTTACCCGAACCTCGGGCGGCTGAGCCATGTCCGTCGCCCGTGCAGGTCTGGCAACTCCTGCTCAC
GCATCTGCTGGATAAGCATTATGGTCTCACACTCAATGACACGCCGTTTGGCGACGACGGCGTAATTCAGGCGCACATCA
ACGCCGGTATCTCTCTGTGCGACGCCGTCAACTTCATTGTGGAAAGGTATGAACTGTTGCGCACTGACCACAGCAGCTCC
AGCCTCACCGAGCACTCTTCACTGATTGGTGCCATCGACATCCTGCGTGCCCACCGTGCAACCGGCCTGATAGTGGGCAG
CGGCTACAGCACCATCACCCGCATCACAACGGGCCAGTATCGGGAGGACAAAACACAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT41170 WP_022649087.1 NZ_AP025810:3514447-3514773 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT41170 NZ_AP025810:3514447-3514773 [Enterobacter hormaechei]
ATGCATTCTGAACAATGGGGACTGACGTGCGGTAAAACGCCGTGCTTCAGTGCCAAGCTGGTGCAGGAAGGCAACCGGCT
GCACTTTCTAGCTGACCGAGCAGAGTTTAGTGGCGACTTGAGCGACGATGAGGCACTGCGCCTCGACCAGGCTTTTCCGG
TGATATTGAAGCAGCTGGAACAAATGCTTTCAGCCGGTGAGCTGAATCCCCGCCATCAGCATCGCGTCACTCTGCATCTT
AACGGGCTAACCTGCGAAGCCGACACGCTCGGTTCGCACGGCTACCTTTACATCGCGATTTATCCCTCAGCGGTAGCTAC
CGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References