Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2231977..2232716 Replicon chromosome
Accession NZ_AP025810
Organism Enterobacter hormaechei strain FUJ80060

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGJ58_RS10630 Protein ID WP_022648141.1
Coordinates 2231977..2232462 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGJ58_RS10635 Protein ID WP_003857131.1
Coordinates 2232450..2232716 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ58_RS10600 2227503..2228711 + 1209 WP_001339197.1 IS4-like element ISVsa5 family transposase -
NGJ58_RS10605 (FJMB80060_20750) 2228724..2229155 + 432 WP_251259014.1 alpha/beta hydrolase -
NGJ58_RS10610 (FJMB80060_20760) 2229251..2230015 + 765 WP_022648136.1 SDR family oxidoreductase -
NGJ58_RS10615 (FJMB80060_20780) 2230682..2230945 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGJ58_RS10620 (FJMB80060_20790) 2230920..2231249 - 330 WP_022648139.1 hypothetical protein -
NGJ58_RS10625 (FJMB80060_20800) 2231382..2231951 + 570 WP_022648140.1 hypothetical protein -
NGJ58_RS10630 (FJMB80060_20810) 2231977..2232462 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGJ58_RS10635 (FJMB80060_20820) 2232450..2232716 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGJ58_RS10640 (FJMB80060_20830) 2232780..2233709 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGJ58_RS10645 (FJMB80060_20840) 2233839..2235227 + 1389 WP_022648143.1 MFS transporter -
NGJ58_RS10650 (FJMB80060_20850) 2235206..2235763 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGJ58_RS10655 (FJMB80060_20860) 2235884..2237020 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGJ58_RS10660 (FJMB80060_20870) 2237044..2237622 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2207772..2232716 24944
- flank IS/Tn - - 2227503..2228711 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T41161 WP_022648141.1 NZ_AP025810:c2232462-2231977 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41161 NZ_AP025810:c2232462-2231977 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41161 WP_003857131.1 NZ_AP025810:c2232716-2232450 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41161 NZ_AP025810:c2232716-2232450 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References