Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2220935..2221674 Replicon chromosome
Accession NZ_AP025807
Organism Enterobacter hormaechei strain FUJ80056

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGK22_RS10525 Protein ID WP_022648141.1
Coordinates 2220935..2221420 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK22_RS10530 Protein ID WP_003857131.1
Coordinates 2221408..2221674 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK22_RS10500 (FJMB80056_20610) 2217091..2218113 + 1023 WP_022648135.1 alpha/beta hydrolase -
NGK22_RS10505 (FJMB80056_20620) 2218209..2218973 + 765 WP_023300126.1 SDR family NAD(P)-dependent oxidoreductase -
NGK22_RS10510 (FJMB80056_20640) 2219640..2219903 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGK22_RS10515 (FJMB80056_20650) 2219878..2220207 - 330 WP_022648139.1 hypothetical protein -
NGK22_RS10520 (FJMB80056_20660) 2220340..2220909 + 570 WP_022648140.1 hypothetical protein -
NGK22_RS10525 (FJMB80056_20670) 2220935..2221420 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGK22_RS10530 (FJMB80056_20680) 2221408..2221674 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK22_RS10535 (FJMB80056_20690) 2221738..2222667 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGK22_RS10540 (FJMB80056_20700) 2222797..2224185 + 1389 WP_022648143.1 MFS transporter -
NGK22_RS10545 (FJMB80056_20710) 2224164..2224721 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGK22_RS10550 (FJMB80056_20720) 2224842..2225978 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGK22_RS10555 (FJMB80056_20730) 2226002..2226580 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2198068..2224721 26653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T41145 WP_022648141.1 NZ_AP025807:c2221420-2220935 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41145 NZ_AP025807:c2221420-2220935 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41145 WP_003857131.1 NZ_AP025807:c2221674-2221408 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41145 NZ_AP025807:c2221674-2221408 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References