Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2233041..2233780 Replicon chromosome
Accession NZ_AP025804
Organism Enterobacter hormaechei strain FUJ80053

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGK45_RS10655 Protein ID WP_022648141.1
Coordinates 2233041..2233526 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK45_RS10660 Protein ID WP_003857131.1
Coordinates 2233514..2233780 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK45_RS10625 2228567..2229775 + 1209 WP_001339197.1 IS4-like element ISVsa5 family transposase -
NGK45_RS10630 (FJMB80053_20780) 2229788..2230219 + 432 WP_251259014.1 alpha/beta hydrolase -
NGK45_RS10635 (FJMB80053_20790) 2230315..2231079 + 765 WP_022648136.1 SDR family oxidoreductase -
NGK45_RS10640 (FJMB80053_20810) 2231746..2232009 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGK45_RS10645 (FJMB80053_20820) 2231984..2232313 - 330 WP_022648139.1 hypothetical protein -
NGK45_RS10650 (FJMB80053_20830) 2232446..2233015 + 570 WP_022648140.1 hypothetical protein -
NGK45_RS10655 (FJMB80053_20840) 2233041..2233526 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGK45_RS10660 (FJMB80053_20850) 2233514..2233780 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK45_RS10665 (FJMB80053_20860) 2233844..2234773 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGK45_RS10670 (FJMB80053_20870) 2234903..2236291 + 1389 WP_022648143.1 MFS transporter -
NGK45_RS10675 (FJMB80053_20880) 2236270..2236827 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGK45_RS10680 (FJMB80053_20890) 2236948..2238084 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGK45_RS10685 (FJMB80053_20900) 2238108..2238686 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2228567..2229775 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T41129 WP_022648141.1 NZ_AP025804:c2233526-2233041 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41129 NZ_AP025804:c2233526-2233041 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41129 WP_003857131.1 NZ_AP025804:c2233780-2233514 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41129 NZ_AP025804:c2233780-2233514 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References