Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3728626..3729283 Replicon chromosome
Accession NZ_AP025801
Organism Enterobacter hormaechei strain FUJ80024

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag NGJ01_RS17680 Protein ID WP_022649305.1
Coordinates 3728626..3729036 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGJ01_RS17685 Protein ID WP_003863437.1
Coordinates 3729017..3729283 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ01_RS17660 (FJMB80024_34680) 3724624..3726357 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
NGJ01_RS17665 (FJMB80024_34690) 3726363..3727076 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGJ01_RS17670 (FJMB80024_34700) 3727105..3728001 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGJ01_RS17675 (FJMB80024_34710) 3728103..3728624 + 522 WP_015571793.1 flavodoxin FldB -
NGJ01_RS17680 (FJMB80024_34720) 3728626..3729036 - 411 WP_022649305.1 protein YgfX Toxin
NGJ01_RS17685 (FJMB80024_34730) 3729017..3729283 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGJ01_RS17690 (FJMB80024_34740) 3729578..3730558 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGJ01_RS17695 (FJMB80024_34760) 3731082..3731741 - 660 WP_022649307.1 hemolysin III family protein -
NGJ01_RS17700 (FJMB80024_34770) 3732008..3732739 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41123 WP_022649305.1 NZ_AP025801:c3729036-3728626 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41123 NZ_AP025801:c3729036-3728626 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41123 WP_003863437.1 NZ_AP025801:c3729283-3729017 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41123 NZ_AP025801:c3729283-3729017 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9


Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References