Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3543527..3544266 Replicon chromosome
Accession NZ_AP025799
Organism Enterobacter hormaechei strain FUJ80023

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag NGJ00_RS17040 Protein ID WP_022649088.1
Coordinates 3543886..3544266 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag NGJ00_RS17035 Protein ID WP_022649087.1
Coordinates 3543527..3543853 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ00_RS17020 (FJMB80023_33280) 3539421..3542081 - 2661 WP_022649084.1 antiviral RADAR system adenosine triphosphatase RdrA -
NGJ00_RS17025 (FJMB80023_33290) 3542711..3543034 + 324 WP_022649085.1 antirestriction protein -
NGJ00_RS17030 (FJMB80023_33300) 3543049..3543516 + 468 WP_022649086.1 DNA repair protein RadC -
NGJ00_RS17035 (FJMB80023_33310) 3543527..3543853 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NGJ00_RS17040 (FJMB80023_33320) 3543886..3544266 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
NGJ00_RS17045 (FJMB80023_33330) 3544263..3544490 + 228 WP_022649089.1 DUF5983 family protein -
NGJ00_RS17050 (FJMB80023_33340) 3544882..3545175 + 294 WP_022649090.1 contact-dependent growth inhibition system immunity protein -
NGJ00_RS17055 (FJMB80023_33350) 3545519..3546835 - 1317 WP_022649091.1 amidase family protein -
NGJ00_RS17060 (FJMB80023_33360) 3546890..3548185 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3520418..3545175 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T41106 WP_022649088.1 NZ_AP025799:3543886-3544266 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T41106 NZ_AP025799:3543886-3544266 [Enterobacter hormaechei]
ATGCAAACTTTACCGTTACCCGAACCTCGGGCGGCTGAGCCATGTCCGTCGCCCGTGCAGGTCTGGCAACTCCTGCTCAC
GCATCTGCTGGATAAGCATTATGGTCTCACACTCAATGACACGCCGTTTGGCGACGACGGCGTAATTCAGGCGCACATCA
ACGCCGGTATCTCTCTGTGCGACGCCGTCAACTTCATTGTGGAAAGGTATGAACTGTTGCGCACTGACCACAGCAGCTCC
AGCCTCACCGAGCACTCTTCACTGATTGGTGCCATCGACATCCTGCGTGCCCACCGTGCAACCGGCCTGATAGTGGGCAG
CGGCTACAGCACCATCACCCGCATCACAACGGGCCAGTATCGGGAGGACAAAACACAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT41106 WP_022649087.1 NZ_AP025799:3543527-3543853 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT41106 NZ_AP025799:3543527-3543853 [Enterobacter hormaechei]
ATGCATTCTGAACAATGGGGACTGACGTGCGGTAAAACGCCGTGCTTCAGTGCCAAGCTGGTGCAGGAAGGCAACCGGCT
GCACTTTCTAGCTGACCGAGCAGAGTTTAGTGGCGACTTGAGCGACGATGAGGCACTGCGCCTCGACCAGGCTTTTCCGG
TGATATTGAAGCAGCTGGAACAAATGCTTTCAGCCGGTGAGCTGAATCCCCGCCATCAGCATCGCGTCACTCTGCATCTT
AACGGGCTAACCTGCGAAGCCGACACGCTCGGTTCGCACGGCTACCTTTACATCGCGATTTATCCCTCAGCGGTAGCTAC
CGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References