Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2226624..2227363 Replicon chromosome
Accession NZ_AP025799
Organism Enterobacter hormaechei strain FUJ80023

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGJ00_RS10605 Protein ID WP_022648141.1
Coordinates 2226624..2227109 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGJ00_RS10610 Protein ID WP_003857131.1
Coordinates 2227097..2227363 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ00_RS10575 2222150..2223358 + 1209 WP_001339197.1 IS4-like element ISVsa5 family transposase -
NGJ00_RS10580 (FJMB80023_20600) 2223371..2223802 + 432 WP_251259014.1 alpha/beta hydrolase -
NGJ00_RS10585 (FJMB80023_20610) 2223898..2224662 + 765 WP_022648136.1 SDR family oxidoreductase -
NGJ00_RS10590 (FJMB80023_20630) 2225329..2225592 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGJ00_RS10595 (FJMB80023_20640) 2225567..2225896 - 330 WP_022648139.1 hypothetical protein -
NGJ00_RS10600 (FJMB80023_20650) 2226029..2226598 + 570 WP_022648140.1 hypothetical protein -
NGJ00_RS10605 (FJMB80023_20660) 2226624..2227109 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGJ00_RS10610 (FJMB80023_20670) 2227097..2227363 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGJ00_RS10615 (FJMB80023_20680) 2227427..2228356 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGJ00_RS10620 (FJMB80023_20690) 2228486..2229874 + 1389 WP_022648143.1 MFS transporter -
NGJ00_RS10625 (FJMB80023_20700) 2229853..2230410 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGJ00_RS10630 (FJMB80023_20710) 2230531..2231667 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGJ00_RS10635 (FJMB80023_20720) 2231691..2232269 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2202419..2227363 24944
- flank IS/Tn - - 2222150..2223358 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T41097 WP_022648141.1 NZ_AP025799:c2227109-2226624 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41097 NZ_AP025799:c2227109-2226624 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41097 WP_003857131.1 NZ_AP025799:c2227363-2227097 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41097 NZ_AP025799:c2227363-2227097 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References