Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3754454..3755111 Replicon chromosome
Accession NZ_AP025797
Organism Enterobacter hormaechei strain FUJ80022

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag NGK25_RS17915 Protein ID WP_022649305.1
Coordinates 3754454..3754864 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGK25_RS17920 Protein ID WP_003863437.1
Coordinates 3754845..3755111 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK25_RS17895 (FJMB80022_35090) 3750452..3752185 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
NGK25_RS17900 (FJMB80022_35100) 3752191..3752904 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGK25_RS17905 (FJMB80022_35110) 3752933..3753829 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGK25_RS17910 (FJMB80022_35120) 3753931..3754452 + 522 WP_015571793.1 flavodoxin FldB -
NGK25_RS17915 (FJMB80022_35130) 3754454..3754864 - 411 WP_022649305.1 protein YgfX Toxin
NGK25_RS17920 (FJMB80022_35140) 3754845..3755111 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGK25_RS17925 (FJMB80022_35150) 3755406..3756386 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGK25_RS17930 (FJMB80022_35170) 3756910..3757569 - 660 WP_022649307.1 hemolysin III family protein -
NGK25_RS17935 (FJMB80022_35180) 3757836..3758567 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41091 WP_022649305.1 NZ_AP025797:c3754864-3754454 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41091 NZ_AP025797:c3754864-3754454 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41091 WP_003863437.1 NZ_AP025797:c3755111-3754845 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41091 NZ_AP025797:c3755111-3754845 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References