Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3789666..3790323 Replicon chromosome
Accession NZ_AP025795
Organism Enterobacter hormaechei strain FUJ80019

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag NGJ92_RS18070 Protein ID WP_022649305.1
Coordinates 3789666..3790076 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGJ92_RS18075 Protein ID WP_003863437.1
Coordinates 3790057..3790323 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ92_RS18050 (FJMB80019_35420) 3785664..3787397 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
NGJ92_RS18055 (FJMB80019_35430) 3787403..3788116 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGJ92_RS18060 (FJMB80019_35440) 3788145..3789041 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGJ92_RS18065 (FJMB80019_35450) 3789143..3789664 + 522 WP_015571793.1 flavodoxin FldB -
NGJ92_RS18070 (FJMB80019_35460) 3789666..3790076 - 411 WP_022649305.1 protein YgfX Toxin
NGJ92_RS18075 (FJMB80019_35470) 3790057..3790323 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGJ92_RS18080 (FJMB80019_35480) 3790618..3791598 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGJ92_RS18085 (FJMB80019_35500) 3792122..3792781 - 660 WP_022649307.1 hemolysin III family protein -
NGJ92_RS18090 (FJMB80019_35510) 3793048..3793779 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41075 WP_022649305.1 NZ_AP025795:c3790076-3789666 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41075 NZ_AP025795:c3790076-3789666 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41075 WP_003863437.1 NZ_AP025795:c3790323-3790057 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41075 NZ_AP025795:c3790323-3790057 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References