Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3775205..3775862 Replicon chromosome
Accession NZ_AP025792
Organism Enterobacter hormaechei strain FUJ80017

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag NGK49_RS18070 Protein ID WP_022649305.1
Coordinates 3775205..3775615 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGK49_RS18075 Protein ID WP_003863437.1
Coordinates 3775596..3775862 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK49_RS18050 (FJMB80017_35550) 3771203..3772936 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
NGK49_RS18055 (FJMB80017_35560) 3772942..3773655 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGK49_RS18060 (FJMB80017_35570) 3773684..3774580 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGK49_RS18065 (FJMB80017_35580) 3774682..3775203 + 522 WP_015571793.1 flavodoxin FldB -
NGK49_RS18070 (FJMB80017_35590) 3775205..3775615 - 411 WP_022649305.1 protein YgfX Toxin
NGK49_RS18075 (FJMB80017_35600) 3775596..3775862 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGK49_RS18080 (FJMB80017_35610) 3776157..3777137 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGK49_RS18085 (FJMB80017_35630) 3777661..3778320 - 660 WP_022649307.1 hemolysin III family protein -
NGK49_RS18090 (FJMB80017_35640) 3778587..3779318 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41059 WP_022649305.1 NZ_AP025792:c3775615-3775205 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41059 NZ_AP025792:c3775615-3775205 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41059 WP_003863437.1 NZ_AP025792:c3775862-3775596 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41059 NZ_AP025792:c3775862-3775596 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References