Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2297555..2298294 Replicon chromosome
Accession NZ_AP025790
Organism Enterobacter hormaechei strain FUJ80014

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGK33_RS11015 Protein ID WP_022648141.1
Coordinates 2297555..2298040 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK33_RS11020 Protein ID WP_003857131.1
Coordinates 2298028..2298294 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK33_RS10990 (FJMB80014_21490) 2293711..2294733 + 1023 WP_022648135.1 alpha/beta hydrolase -
NGK33_RS10995 (FJMB80014_21500) 2294829..2295593 + 765 WP_022648136.1 SDR family oxidoreductase -
NGK33_RS11000 (FJMB80014_21520) 2296260..2296523 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGK33_RS11005 (FJMB80014_21530) 2296498..2296827 - 330 WP_022648139.1 hypothetical protein -
NGK33_RS11010 (FJMB80014_21540) 2296960..2297529 + 570 WP_022648140.1 hypothetical protein -
NGK33_RS11015 (FJMB80014_21550) 2297555..2298040 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGK33_RS11020 (FJMB80014_21560) 2298028..2298294 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK33_RS11025 (FJMB80014_21570) 2298358..2299287 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGK33_RS11030 (FJMB80014_21580) 2299417..2300805 + 1389 WP_022648143.1 MFS transporter -
NGK33_RS11035 (FJMB80014_21590) 2300784..2301341 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGK33_RS11040 (FJMB80014_21600) 2301462..2302598 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGK33_RS11045 (FJMB80014_21610) 2302622..2303200 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2274688..2298294 23606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(58-151)

Antitoxin

(6-82)


Sequences


Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T41033 WP_022648141.1 NZ_AP025790:c2298040-2297555 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41033 NZ_AP025790:c2298040-2297555 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41033 WP_003857131.1 NZ_AP025790:c2298294-2298028 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41033 NZ_AP025790:c2298294-2298028 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61


Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References