Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3797568..3798225 Replicon chromosome
Accession NZ_AP025787
Organism Enterobacter hormaechei strain FUJ80013

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag NGJ87_RS18120 Protein ID WP_022649305.1
Coordinates 3797568..3797978 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGJ87_RS18125 Protein ID WP_003863437.1
Coordinates 3797959..3798225 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ87_RS18100 (FJMB80013_35290) 3793566..3795299 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
NGJ87_RS18105 (FJMB80013_35300) 3795305..3796018 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGJ87_RS18110 (FJMB80013_35310) 3796047..3796943 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGJ87_RS18115 (FJMB80013_35320) 3797045..3797566 + 522 WP_015571793.1 flavodoxin FldB -
NGJ87_RS18120 (FJMB80013_35330) 3797568..3797978 - 411 WP_022649305.1 protein YgfX Toxin
NGJ87_RS18125 (FJMB80013_35340) 3797959..3798225 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGJ87_RS18130 (FJMB80013_35350) 3798520..3799500 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGJ87_RS18135 (FJMB80013_35370) 3800024..3800683 - 660 WP_022649307.1 hemolysin III family protein -
NGJ87_RS18140 (FJMB80013_35380) 3800950..3801681 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T41027 WP_022649305.1 NZ_AP025787:c3797978-3797568 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T41027 NZ_AP025787:c3797978-3797568 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT41027 WP_003863437.1 NZ_AP025787:c3798225-3797959 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT41027 NZ_AP025787:c3798225-3797959 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References