Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2301566..2302305 Replicon chromosome
Accession NZ_AP025787
Organism Enterobacter hormaechei strain FUJ80013

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGJ87_RS11045 Protein ID WP_022648141.1
Coordinates 2301566..2302051 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGJ87_RS11050 Protein ID WP_003857131.1
Coordinates 2302039..2302305 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ87_RS11020 (FJMB80013_21460) 2297722..2298744 + 1023 WP_022648135.1 alpha/beta hydrolase -
NGJ87_RS11025 (FJMB80013_21470) 2298840..2299604 + 765 WP_022648136.1 SDR family oxidoreductase -
NGJ87_RS11030 (FJMB80013_21490) 2300271..2300534 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGJ87_RS11035 (FJMB80013_21500) 2300509..2300838 - 330 WP_022648139.1 hypothetical protein -
NGJ87_RS11040 (FJMB80013_21510) 2300971..2301540 + 570 WP_022648140.1 hypothetical protein -
NGJ87_RS11045 (FJMB80013_21520) 2301566..2302051 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGJ87_RS11050 (FJMB80013_21530) 2302039..2302305 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGJ87_RS11055 (FJMB80013_21540) 2302369..2303298 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGJ87_RS11060 (FJMB80013_21550) 2303428..2304816 + 1389 WP_022648143.1 MFS transporter -
NGJ87_RS11065 (FJMB80013_21560) 2304795..2305352 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGJ87_RS11070 (FJMB80013_21570) 2305473..2306609 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGJ87_RS11075 (FJMB80013_21580) 2306633..2307211 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2278699..2302305 23606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T41017 WP_022648141.1 NZ_AP025787:c2302051-2301566 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T41017 NZ_AP025787:c2302051-2301566 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT41017 WP_003857131.1 NZ_AP025787:c2302305-2302039 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT41017 NZ_AP025787:c2302305-2302039 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References