Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3465760..3466499 Replicon chromosome
Accession NZ_AP025784
Organism Enterobacter hormaechei strain FUJ80012

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag NGJ22_RS16425 Protein ID WP_022649088.1
Coordinates 3466119..3466499 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag NGJ22_RS16420 Protein ID WP_022649087.1
Coordinates 3465760..3466086 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ22_RS16405 (FJMB80012_32180) 3461654..3464314 - 2661 WP_022649084.1 antiviral RADAR system adenosine triphosphatase RdrA -
NGJ22_RS16410 (FJMB80012_32190) 3464944..3465267 + 324 WP_022649085.1 antirestriction protein -
NGJ22_RS16415 (FJMB80012_32200) 3465282..3465749 + 468 WP_022649086.1 DNA repair protein RadC -
NGJ22_RS16420 (FJMB80012_32210) 3465760..3466086 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NGJ22_RS16425 (FJMB80012_32220) 3466119..3466499 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
NGJ22_RS16430 (FJMB80012_32230) 3466496..3466723 + 228 WP_022649089.1 DUF5983 family protein -
NGJ22_RS16435 (FJMB80012_32240) 3467115..3467408 + 294 WP_022649090.1 contact-dependent growth inhibition system immunity protein -
NGJ22_RS16440 (FJMB80012_32250) 3467752..3469068 - 1317 WP_022649091.1 amidase family protein -
NGJ22_RS16445 (FJMB80012_32260) 3469123..3470418 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T41010 WP_022649088.1 NZ_AP025784:3466119-3466499 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T41010 NZ_AP025784:3466119-3466499 [Enterobacter hormaechei]
ATGCAAACTTTACCGTTACCCGAACCTCGGGCGGCTGAGCCATGTCCGTCGCCCGTGCAGGTCTGGCAACTCCTGCTCAC
GCATCTGCTGGATAAGCATTATGGTCTCACACTCAATGACACGCCGTTTGGCGACGACGGCGTAATTCAGGCGCACATCA
ACGCCGGTATCTCTCTGTGCGACGCCGTCAACTTCATTGTGGAAAGGTATGAACTGTTGCGCACTGACCACAGCAGCTCC
AGCCTCACCGAGCACTCTTCACTGATTGGTGCCATCGACATCCTGCGTGCCCACCGTGCAACCGGCCTGATAGTGGGCAG
CGGCTACAGCACCATCACCCGCATCACAACGGGCCAGTATCGGGAGGACAAAACACAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT41010 WP_022649087.1 NZ_AP025784:3465760-3466086 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT41010 NZ_AP025784:3465760-3466086 [Enterobacter hormaechei]
ATGCATTCTGAACAATGGGGACTGACGTGCGGTAAAACGCCGTGCTTCAGTGCCAAGCTGGTGCAGGAAGGCAACCGGCT
GCACTTTCTAGCTGACCGAGCAGAGTTTAGTGGCGACTTGAGCGACGATGAGGCACTGCGCCTCGACCAGGCTTTTCCGG
TGATATTGAAGCAGCTGGAACAAATGCTTTCAGCCGGTGAGCTGAATCCCCGCCATCAGCATCGCGTCACTCTGCATCTT
AACGGGCTAACCTGCGAAGCCGACACGCTCGGTTCGCACGGCTACCTTTACATCGCGATTTATCCCTCAGCGGTAGCTAC
CGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References