Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3521470..3522209 Replicon chromosome
Accession NZ_AP025782
Organism Enterobacter hormaechei strain FUJ80011

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag NGK66_RS16780 Protein ID WP_022649088.1
Coordinates 3521829..3522209 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag NGK66_RS16775 Protein ID WP_022649087.1
Coordinates 3521470..3521796 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK66_RS16760 (FJMB80011_32770) 3517364..3520024 - 2661 WP_022649084.1 antiviral RADAR system adenosine triphosphatase RdrA -
NGK66_RS16765 (FJMB80011_32780) 3520654..3520977 + 324 WP_022649085.1 antirestriction protein -
NGK66_RS16770 (FJMB80011_32790) 3520992..3521459 + 468 WP_022649086.1 DNA repair protein RadC -
NGK66_RS16775 (FJMB80011_32800) 3521470..3521796 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NGK66_RS16780 (FJMB80011_32810) 3521829..3522209 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
NGK66_RS16785 (FJMB80011_32820) 3522206..3522433 + 228 WP_022649089.1 DUF5983 family protein -
NGK66_RS16790 (FJMB80011_32830) 3522825..3523118 + 294 WP_022649090.1 contact-dependent growth inhibition system immunity protein -
NGK66_RS16795 (FJMB80011_32840) 3523462..3524778 - 1317 WP_022649091.1 amidase family protein -
NGK66_RS16800 (FJMB80011_32850) 3524833..3526128 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3498361..3523118 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T40994 WP_022649088.1 NZ_AP025782:3521829-3522209 [Enterobacter hormaechei]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T40994 NZ_AP025782:3521829-3522209 [Enterobacter hormaechei]
ATGCAAACTTTACCGTTACCCGAACCTCGGGCGGCTGAGCCATGTCCGTCGCCCGTGCAGGTCTGGCAACTCCTGCTCAC
GCATCTGCTGGATAAGCATTATGGTCTCACACTCAATGACACGCCGTTTGGCGACGACGGCGTAATTCAGGCGCACATCA
ACGCCGGTATCTCTCTGTGCGACGCCGTCAACTTCATTGTGGAAAGGTATGAACTGTTGCGCACTGACCACAGCAGCTCC
AGCCTCACCGAGCACTCTTCACTGATTGGTGCCATCGACATCCTGCGTGCCCACCGTGCAACCGGCCTGATAGTGGGCAG
CGGCTACAGCACCATCACCCGCATCACAACGGGCCAGTATCGGGAGGACAAAACACAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT40994 WP_022649087.1 NZ_AP025782:3521470-3521796 [Enterobacter hormaechei]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT40994 NZ_AP025782:3521470-3521796 [Enterobacter hormaechei]
ATGCATTCTGAACAATGGGGACTGACGTGCGGTAAAACGCCGTGCTTCAGTGCCAAGCTGGTGCAGGAAGGCAACCGGCT
GCACTTTCTAGCTGACCGAGCAGAGTTTAGTGGCGACTTGAGCGACGATGAGGCACTGCGCCTCGACCAGGCTTTTCCGG
TGATATTGAAGCAGCTGGAACAAATGCTTTCAGCCGGTGAGCTGAATCCCCGCCATCAGCATCGCGTCACTCTGCATCTT
AACGGGCTAACCTGCGAAGCCGACACGCTCGGTTCGCACGGCTACCTTTACATCGCGATTTATCCCTCAGCGGTAGCTAC
CGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References