Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2227962..2228701 Replicon chromosome
Accession NZ_AP025777
Organism Enterobacter hormaechei strain FUJ80007

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGJ89_RS10615 Protein ID WP_022648141.1
Coordinates 2227962..2228447 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGJ89_RS10620 Protein ID WP_003857131.1
Coordinates 2228435..2228701 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ89_RS10585 2223488..2224696 + 1209 WP_001339197.1 IS4-like element ISVsa5 family transposase -
NGJ89_RS10590 (FJMB80007_20650) 2224709..2225140 + 432 WP_251259014.1 alpha/beta hydrolase -
NGJ89_RS10595 (FJMB80007_20660) 2225236..2226000 + 765 WP_022648136.1 SDR family oxidoreductase -
NGJ89_RS10600 (FJMB80007_20670) 2226667..2226930 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGJ89_RS10605 (FJMB80007_20680) 2226905..2227234 - 330 WP_022648139.1 hypothetical protein -
NGJ89_RS10610 (FJMB80007_20690) 2227367..2227936 + 570 WP_022648140.1 hypothetical protein -
NGJ89_RS10615 (FJMB80007_20700) 2227962..2228447 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGJ89_RS10620 (FJMB80007_20710) 2228435..2228701 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGJ89_RS10625 (FJMB80007_20720) 2228765..2229694 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGJ89_RS10630 (FJMB80007_20730) 2229824..2231212 + 1389 WP_022648143.1 MFS transporter -
NGJ89_RS10635 (FJMB80007_20740) 2231191..2231748 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGJ89_RS10640 (FJMB80007_20750) 2231869..2233005 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGJ89_RS10645 (FJMB80007_20760) 2233029..2233607 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2203757..2231748 27991
- flank IS/Tn - - 2223488..2224696 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T40953 WP_022648141.1 NZ_AP025777:c2228447-2227962 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T40953 NZ_AP025777:c2228447-2227962 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT40953 WP_003857131.1 NZ_AP025777:c2228701-2228435 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT40953 NZ_AP025777:c2228701-2228435 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References